Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.47 |
| ▸ | GPR3 | P46089 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20115859 | 0.84 | IMPDH2 (0.47) | EGFRSRCIMPDH2GPR3ALDH1A1 | |
| SCHEMBL18030919 | 0.81 | GPR3 (0.52) | EGFRSRCIMPDH2GPR3ALDH1A1 | |
| SCHEMBL18030949 | 0.77 | EGFR (0.51) | EGFRSRCIMPDH2GPR3ALDH1A1 | |
| SCHEMBL18030937 | 0.77 | KDM4E (0.50) | EGFRSRCIMPDH2GPR3ALDH1A1 | |
| SCHEMBL14313953 | 0.76 | GPR3 (0.71) | GPR3ALDH1A1HSD17B10NQO2L3MBTL1 | |
| SCHEMBL24211213 | 0.76 | EGFR (0.47) | EGFRSRCIMPDH2GPR3ALDH1A1 | |
| SCHEMBL24278996 | 0.75 | EGFR (0.36) | EGFRSRCIMPDH2GPR3ALDH1A1 | |
| SCHEMBL20115855 | 0.73 | KDM4E (0.68) | EGFRSRCIMPDH2GPR3ALDH1A1 | |
| SCHEMBL18030933 | 0.73 | IMPDH2 (0.46) | EGFRSRCIMPDH2GPR3ALDH1A1 | |
| SCHEMBL18365441 | 0.73 | EGFR (0.62) | EGFRSRCIMPDH2GPR3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3061759-B1 | NITRILE SUBSTITUTED DIBENZOFURANS | IDEMITSU KOSAN CO (JP) | 2019-12-25 | — | — | EP | disclosed |
| US-20170098781-A1 | NEW DIBENZOFURANS AND DIBENZOTHIOPHENES | IDEMITSU KOSAN CO., LTD. (JP) | 2017-04-06 | — | — | US | disclosed |
| EP-3061759-A1 | NITRILE SUBSTITUTED DIBENZOFURANS | Idemitsu Kosan Co., Ltd (JP) | 2016-08-31 | — | — | EP | disclosed |
| US-20160248026-A1 | NITRILE SUBSTITUTED DIBENZOFURANS | IDEMITSU KOSAN CO., LTD. (JP) | 2016-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170098781-A1 | NEW DIBENZOFURANS AND DIBENZOTHIOPHENES | DBF4, DDT, SLC43A3 | EGFR 2331/4885SRC 3464/4885IMPDH2 1250/4885 |
| US-20160248026-A1 | NITRILE SUBSTITUTED DIBENZOFURANS | DBF4, NXF1, NCF1 | EGFR 2124/4885SRC 3192/4885IMPDH2 2051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.