Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 3/20 | 0.45 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22598030 | 0.88 | STIM1 (0.55) | STIM1ORAI1MAPTTP53MEN1 | |
| SCHEMBL16017429 | 0.80 | SMN1; SMN2 (0.54) | MAPTTP53MEN1KMT2ATDP1 | |
| SCHEMBL24178087 | 0.78 | STIM1 (0.45) | STIM1ORAI1MAPTTP53MEN1 | |
| SCHEMBL14887684 | 0.78 | MAPT (0.55) | STIM1ORAI1MAPTTP53MEN1 | |
| SCHEMBL30534421 | 0.77 | CHEK2 (0.37) | STIM1ORAI1 | |
| SCHEMBL10201298 | 0.74 | STIM1 (0.56) | STIM1ORAI1MAPTTP53KMT2A | |
| SCHEMBL16463664 | 0.74 | STIM1 (0.52) | STIM1ORAI1MEN1KMT2APOLB | |
| SCHEMBL10201066 | 0.73 | STIM1 (0.75) | STIM1ORAI1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24048617 | 0.72 | SMN1; SMN2 (0.41) | MAPTTP53MEN1KMT2ATDP1 | |
| SCHEMBL18038399 | 0.72 | STIM1 (0.39) | STIM1ORAI1JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12544371-B2 | Methods and compositions for treating acute lung injury and acute respiratory distress syndrome | CALCIMEDICA, INC. (US) | 2026-02-10 | — | — | US | claimed |
| US-20250120969-A1 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATION INJURY IN THE LUNGS | AVENUE CAPITAL MANAGEMENT II, L.P. | 2025-04-17 | — | — | US | claimed |
| EP-4465988-A1 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATION INJURY IN THE LUNGS | Calcimedica, Inc. (US) | 2024-11-27 | — | — | EP | claimed |
| CN-118871110-A | Methods and compositions for treating inflammatory lesions of the lung | 钙医学公司 | 2024-10-29 | — | — | CN | claimed |
| WO-2023141523-A1 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATION INJURY IN THE LUNGS | CALCIMEDICA, INC. (US) | 2023-07-27 | — | — | WO | claimed |
| US-20230226058-A1 | METHODS AND COMPOSITIONS FOR TREATING ACUTE KIDNEY INJURY | AVENUE CAPITAL MANAGEMENT II, L.P. | 2023-07-20 | — | — | US | claimed |
| EP-3261641-B1 | PANCREATITIS TREATMENT | CALCIMEDICA INC (US) | 2023-07-12 | — | — | EP | claimed |
| CN-116261468-A | Methods and compositions for treating acute kidney injury | 钙医学公司 | 2023-06-13 | — | — | CN | claimed |
| US-20230120819-A1 | METHODS AND COMPOSITIONS FOR TREATING ACUTE LUNG INJURY AND ACUTE RESPIRATORY DISTRESS SYNDROME | AVENUE CAPITAL MANAGEMENT II, L.P. | 2023-04-20 | — | — | US | claimed |
| EP-4153179-A1 | METHODS AND COMPOSITIONS FOR TREATING ACUTE KIDNEY INJURY | Calcimedica, Inc. (US) | 2023-03-29 | — | — | EP | claimed |
| CN-115835878-A | Methods and compositions for treating acute lung injury and acute respiratory distress syndrome | 钙医学公司 | 2023-03-21 | — | — | CN | claimed |
| EP-4121089-A1 | METHODS AND COMPOSITIONS FOR TREATING ACUTE LUNG INJURY AND ACUTE RESPIRATORY DISTRESS SYNDROME | Calcimedica, Inc. (US) | 2023-01-25 | — | — | EP | claimed |
| US-11311535-B2 | Pancreatitis treatment | CALCIMEDICA, INC. (US) | 2022-04-26 | — | — | US | claimed |
| WO-2021236820-A1 | METHODS AND COMPOSITIONS FOR TREATING ACUTE KIDNEY INJURY | CALCIMEDICA, INC. (US) | 2021-11-25 | — | — | WO | claimed |
| WO-2021189013-A1 | METHODS AND COMPOSITIONS FOR TREATING ACUTE LUNG INJURY AND ACUTE RESPIRATORY DISTRESS SYNDROME | CALCIMEDICA, INC. (US) | 2021-09-23 | — | — | WO | claimed |
| US-20180235958-A1 | PANCREATITIS TREATMENT | AVENUE CAPITAL MANAGEMENT II, L.P. | 2018-08-23 | — | — | US | claimed |
| EP-3261641-A1 | PANCREATITIS TREATMENT | Calcimedica, Inc. (US) | 2018-01-03 | — | — | EP | claimed |
| WO-2016138472-A1 | PANCREATITIS TREATMENT | CALCIMEDICA, INC. (US) | 2016-09-01 | — | — | WO | claimed |
| US-12544371-B2 | Methods and compositions for treating acute lung injury and acute respiratory distress syndrome | CALCIMEDICA, INC. (US) | 2026-02-10 | — | — | US | disclosed |
| WO-2016138472-A1 | PANCREATITIS TREATMENT | CALCIMEDICA, INC. (US) | 2016-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12544371-B2 | Methods and compositions for treating acute lung injury and acute respiratory distress syndrome | ORAI1, MAVS, CASR | STIM1 231/4885ORAI1 1/4885MAPT 1566/4885 |
| US-20250120969-A1 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATION INJURY IN THE LUNGS | IL1B, MAVS, MMP8 | STIM1 852/4885ORAI1 92/4885MAPT 3314/4885 |
| US-20230120819-A1 | METHODS AND COMPOSITIONS FOR TREATING ACUTE LUNG INJURY AND ACUTE RESPIRATORY DISTRESS SYNDROME | MAVS, ATF1, IL1B | STIM1 943/4885ORAI1 68/4885MAPT 4002/4885 |
| US-20230226058-A1 | METHODS AND COMPOSITIONS FOR TREATING ACUTE KIDNEY INJURY | CAMKK2, CAMKK1, ATF1 | STIM1 451/4885ORAI1 76/4885MAPT 4289/4885 |
| US-11311535-B2 | Pancreatitis treatment | IAPP, PNLIP, VIP | STIM1 249/4885ORAI1 40/4885MAPT 3609/4885 |
| US-20180235958-A1 | PANCREATITIS TREATMENT | IAPP, PNLIP, VIP | STIM1 249/4885ORAI1 40/4885MAPT 3609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.