Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.51 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18038963 | 0.89 | ALDH1A1 (0.48) | ALDH1A1LMNAPOLBSMN1; SMN2NPSR1 | |
| SCHEMBL18038948 | 0.89 | ALDH1A1 (0.60) | ALDH1A1LMNAPOLBSMN1; SMN2NPSR1 | |
| SCHEMBL18038954 | 0.88 | L3MBTL1 (0.56) | ALDH1A1LMNAPOLBSMN1; SMN2NPSR1 | |
| SCHEMBL18038989 | 0.88 | L3MBTL1 (0.56) | ALDH1A1LMNAPOLBSMN1; SMN2NPSR1 | |
| SCHEMBL18038959 | 0.88 | L3MBTL1 (0.56) | ALDH1A1LMNAPOLBSMN1; SMN2NPSR1 | |
| SCHEMBL21749675 | 0.88 | L3MBTL1 (0.50) | AKR1C3AKR1C1ALDH1A1LMNAPOLB | |
| SCHEMBL18038949 | 0.87 | GAA (0.50) | ALDH1A1LMNAPOLBL3MBTL1HTT | |
| SCHEMBL18039005 | 0.87 | L3MBTL1 (0.47) | ALDH1A1LMNAPOLBSMN1; SMN2NPSR1 | |
| SCHEMBL18038995 | 0.86 | ALDH1A1 (0.49) | ALDH1A1LMNAPOLBL3MBTL1HTT | |
| SCHEMBL18038961 | 0.86 | ALDH1A1 (0.48) | ALDH1A1LMNAPOLBSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11311523-B2 | Pyridinone compound and use thereof | KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION (JP) | 2022-04-26 | — | — | US | disclosed |
| EP-3692992-A1 | METHOD OF SCREENING DOCK1-SELECTIVE INHIBITORS FOR CANCER TREATMENT | Kyushu University National University Corporation (JP) | 2020-08-12 | — | — | EP | disclosed |
| EP-3263133-B1 | PYRIDINONE COMPOUND AND USE THEREOF | UNIV KYUSHU NAT UNIV CORP (JP) | 2020-04-01 | — | — | EP | disclosed |
| US-20200061039-A1 | PYRIDINONE COMPOUND AND USE THEREOF | KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION (JP) | 2020-02-27 | — | — | US | disclosed |
| US-10406141-B2 | Pyridinone compound and use thereof | KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION (JP) | 2019-09-10 | — | — | US | disclosed |
| US-20180028515-A1 | PYRIDINONE COMPOUND AND USE THEREOF | KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION (JP) | 2018-02-01 | — | — | US | disclosed |
| EP-3263133-A1 | PYRIDINONE COMPOUND AND USE THEREOF | Kyushu University, National University Corporation (JP) | 2018-01-03 | — | — | EP | disclosed |
| WO-2016136985-A1 | PYRIDINONE COMPOUND AND USE THEREOF | 国立大学法人九州大学 | 2016-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180028515-A1 | PYRIDINONE COMPOUND AND USE THEREOF | DOCK5, DOCK2, CIB1 | AKR1C3 341/4885AKR1C1 121/4885ALDH1A1 52/4885 |
| US-20200061039-A1 | PYRIDINONE COMPOUND AND USE THEREOF | DOCK5, DOCK2, CIB1 | AKR1C3 368/4885AKR1C1 126/4885ALDH1A1 49/4885 |
| US-10406141-B2 | Pyridinone compound and use thereof | DOCK5, DOCK2, CIB1 | AKR1C3 341/4885AKR1C1 121/4885ALDH1A1 52/4885 |
| US-11311523-B2 | Pyridinone compound and use thereof | DOCK5, DOCK2, CIB1 | AKR1C3 368/4885AKR1C1 126/4885ALDH1A1 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.