Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18038967 | 0.99 | GAA (0.47) | GAACYP1A2CYP2D6PKMCYP2C19 | |
| SCHEMBL30207105 | 0.99 | GAA (0.47) | GAACYP1A2CYP2D6PKMCYP2C19 | |
| SCHEMBL18038984 | 0.91 | HTT (0.48) | GAACYP1A2CYP2D6PKMCYP2C19 | |
| SCHEMBL18038982 | 0.91 | HTT (0.52) | GAACYP1A2CYP2D6PKMCYP2C19 | |
| SCHEMBL18038966 | 0.90 | HTT (0.52) | GAACYP1A2CYP2D6PKMCYP2C19 | |
| SCHEMBL22050495 | 0.89 | GAA (0.44) | GAACYP1A2CYP2D6PKMCYP2C19 | |
| SCHEMBL21749683 | 0.88 | GAA (0.46) | GAACYP1A2CYP2D6PKMCYP2C19 | |
| SCHEMBL22051931 | 0.88 | GAA (0.42) | GAACYP1A2CYP2D6PKMCYP2C19 | |
| SCHEMBL18038965 | 0.88 | L3MBTL1 (0.52) | GAACYP1A2CYP2D6PKMCYP2C19 | |
| SCHEMBL22050826 | 0.88 | GAA (0.45) | GAACYP1A2CYP2D6PKMCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11311523-B2 | Pyridinone compound and use thereof | KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION (JP) | 2022-04-26 | — | — | US | disclosed |
| EP-3692992-A1 | METHOD OF SCREENING DOCK1-SELECTIVE INHIBITORS FOR CANCER TREATMENT | Kyushu University National University Corporation (JP) | 2020-08-12 | — | — | EP | disclosed |
| EP-3263133-B1 | PYRIDINONE COMPOUND AND USE THEREOF | UNIV KYUSHU NAT UNIV CORP (JP) | 2020-04-01 | — | — | EP | disclosed |
| US-20200061039-A1 | PYRIDINONE COMPOUND AND USE THEREOF | KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION (JP) | 2020-02-27 | — | — | US | disclosed |
| US-10406141-B2 | Pyridinone compound and use thereof | KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION (JP) | 2019-09-10 | — | — | US | disclosed |
| US-20180028515-A1 | PYRIDINONE COMPOUND AND USE THEREOF | KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION (JP) | 2018-02-01 | — | — | US | disclosed |
| EP-3263133-A1 | PYRIDINONE COMPOUND AND USE THEREOF | Kyushu University, National University Corporation (JP) | 2018-01-03 | — | — | EP | disclosed |
| WO-2016136985-A1 | PYRIDINONE COMPOUND AND USE THEREOF | 国立大学法人九州大学 | 2016-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180028515-A1 | PYRIDINONE COMPOUND AND USE THEREOF | DOCK5, DOCK2, CIB1 | GAA 4692/4885CYP1A2 2087/4885CYP2D6 1497/4885 |
| US-20200061039-A1 | PYRIDINONE COMPOUND AND USE THEREOF | DOCK5, DOCK2, CIB1 | GAA 4691/4885CYP1A2 2070/4885CYP2D6 1491/4885 |
| US-10406141-B2 | Pyridinone compound and use thereof | DOCK5, DOCK2, CIB1 | GAA 4692/4885CYP1A2 2087/4885CYP2D6 1497/4885 |
| US-11311523-B2 | Pyridinone compound and use thereof | DOCK5, DOCK2, CIB1 | GAA 4691/4885CYP1A2 2070/4885CYP2D6 1491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.