Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.53 |
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18080982 | 0.89 | LMNA (0.54) | ATMSMN1; SMN2MAPTCYP1A2CYP3A4 | |
| SCHEMBL5061105 | 0.83 | MAPT (0.45) | SMN1; SMN2MAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4630496 | 0.82 | EGFR (0.45) | SMN1; SMN2MAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL18010709 | 0.81 | PDE4D (0.48) | SMN1; SMN2MAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL18044477 | 0.81 | SMN1; SMN2 (0.50) | ATMSMN1; SMN2MAPTCYP1A2CYP3A4 | |
| SCHEMBL16690686 | 0.80 | CYP4A11 (0.45) | RAB9ANPC1HPGDLMNAL3MBTL1 | |
| SCHEMBL29179289 | 0.80 | MRGPRX4 (0.51) | ATMSMN1; SMN2RAB9ANPC1HPGD | |
| SCHEMBL2188210 | 0.79 | SMPD1 (0.76) | ATMSMN1; SMN2MAPTCYP1A2CYP3A4 | |
| SCHEMBL2063068 | 0.79 | SMN1; SMN2 (0.73) | ATMSMN1; SMN2MAPTCYP1A2CYP3A4 | |
| SCHEMBL9199787 | 0.79 | LMNA (0.56) | ATMSMN1; SMN2MAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3067351-B1 | COMPOUND HAVING HIGHER INHIBITION OF PROTEIN KINASE G ACTIVITY AND PREPARATION METHOD THEREFOR | JENKEM TECH CO LTD TIANJIN (CN) | 2019-02-06 | — | — | EP | disclosed |
| US-9925171-B2 | Compound having higher inhibitory activity on protein kinase G and preparation method thereof | Jenkem Technology Co., Ltd., (Tianjin) (CN) | 2018-03-27 | — | — | US | disclosed |
| US-9925171-B2 | Compound having higher inhibitory activity on protein kinase G and preparation method thereof | Jenkem Technology Co., Ltd., (Tianjin) (CN) | 2018-03-27 | — | — | US | disclosed |
| US-9925171-B2 | Compound having higher inhibitory activity on protein kinase G and preparation method thereof | Jenkem Technology Co., Ltd., (Tianjin) (CN) | 2018-03-27 | — | — | US | disclosed |
| US-20170119736-A1 | COMPOUND HAVING HIGHER INHIBITORY ACTIVITY ON PROTEIN KINASE G AND PREPARATION METHOD THEREOF | Jenkem Technology Co., Ltd., (Tianjin) (CN) | 2017-05-04 | — | — | US | disclosed |
| US-20170119736-A1 | COMPOUND HAVING HIGHER INHIBITORY ACTIVITY ON PROTEIN KINASE G AND PREPARATION METHOD THEREOF | Jenkem Technology Co., Ltd., (Tianjin) (CN) | 2017-05-04 | — | — | US | disclosed |
| US-20170119736-A1 | COMPOUND HAVING HIGHER INHIBITORY ACTIVITY ON PROTEIN KINASE G AND PREPARATION METHOD THEREOF | Jenkem Technology Co., Ltd., (Tianjin) (CN) | 2017-05-04 | — | — | US | disclosed |
| US-9567319-B2 | Compound having higher inhibitory activity on protein kinase G and preparation method thereof | JENKEM TECHNOLOGY CO. LTD., (TIANJIN) (CN) | 2017-02-14 | — | — | US | disclosed |
| US-9567319-B2 | Compound having higher inhibitory activity on protein kinase G and preparation method thereof | JENKEM TECHNOLOGY CO. LTD., (TIANJIN) (CN) | 2017-02-14 | — | — | US | disclosed |
| US-9567319-B2 | Compound having higher inhibitory activity on protein kinase G and preparation method thereof | JENKEM TECHNOLOGY CO. LTD., (TIANJIN) (CN) | 2017-02-14 | — | — | US | disclosed |
| US-20160304501-A1 | COMPOUND HAVING HIGHER INHIBITORY ACTIVITY ON PROTEIN KINASE G AND PREPARATION METHOD THEREOF | Jenkem Technology Co., Ltd., (Tianjin) (CN) | 2016-10-20 | — | — | US | disclosed |
| US-20160304501-A1 | COMPOUND HAVING HIGHER INHIBITORY ACTIVITY ON PROTEIN KINASE G AND PREPARATION METHOD THEREOF | Jenkem Technology Co., Ltd., (Tianjin) (CN) | 2016-10-20 | — | — | US | disclosed |
| US-20160304501-A1 | COMPOUND HAVING HIGHER INHIBITORY ACTIVITY ON PROTEIN KINASE G AND PREPARATION METHOD THEREOF | Jenkem Technology Co., Ltd., (Tianjin) (CN) | 2016-10-20 | — | — | US | disclosed |
| EP-3067351-A1 | COMPOUND HAVING HIGHER INHIBITION OF PROTEIN KINASE G ACTIVITY AND PREPARATION METHOD THEREFOR | Jenkem Technology Co. Ltd. (Tianjin) (CN) | 2016-09-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160304501-A1 | COMPOUND HAVING HIGHER INHIBITORY ACTIVITY ON PROTEIN KINASE G AND PREPARATION METHOD THEREOF | PRKCG, PRKG2, PKN3 | ATM 842/4885SMN1; SMN2 3558/4885MAPT 4286/4885 |
| US-20170119736-A1 | COMPOUND HAVING HIGHER INHIBITORY ACTIVITY ON PROTEIN KINASE G AND PREPARATION METHOD THEREOF | PRKCG, PRKG2, PKN3 | ATM 842/4885SMN1; SMN2 3558/4885MAPT 4286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.