Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 6/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8451921 | 0.80 | MAP4K4 (0.40) | KDM4ENOTUMIDO1 | |
| SCHEMBL8323540 | 0.78 | NOTUM (0.40) | CTSSNOTUMIDO1 | |
| SCHEMBL8329144 | 0.78 | MAOB (0.42) | CTSSNOTUMIDO1 | |
| SCHEMBL1804807 | 0.77 | AR (0.43) | CTSSCTSKAR | |
| SCHEMBL15949380 | 0.77 | IKBKB (0.41) | KDM4EALDH1A1NOTUMXDHIDO1 | |
| SCHEMBL11031993 | 0.77 | NOTUM (0.39) | CTSSKDM4ENOTUMIDO1 | |
| SCHEMBL9539339 | 0.77 | RORB (0.46) | KDM4EALDH1A1NOTUMIDO1 | |
| SCHEMBL16719324 | 0.77 | CNR2 (0.43) | NOTUMIDO1 | |
| SCHEMBL8809460 | 0.77 | CTSS (0.47) | CTSSKDM4EALDH1A1GAACTSK | |
| SCHEMBL5325379 | 0.76 | TSHR (0.39) | KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0770078-A1 | 8-ARYL-1,6-NAPHTHYRIDIN-5-ONES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-05-02 | — | — | EP | disclosed |
| WO-1996002541-A1 | 8-ARYL-1,6-NAPHTHYRIDIN-5-ONES | F. HOFFMANN-LA ROCHE AG (CH) | 1996-02-01 | — | — | WO | disclosed |