Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18048956 | 0.82 | PLA2G10 (0.42) | PLA2G10PLA2G2APLAUMEN1KMT2A | |
| SCHEMBL18049029 | 0.75 | IKBKB (0.48) | PLA2G10PLA2G2ALTB4RBRD4CYP1A2 | |
| SCHEMBL5739579 | 0.71 | CALM1 (0.46) | LTB4RCYP1A2CYP2D6CYP3A4CYP2C9 | |
| SCHEMBL3462235 | 0.71 | PLA2G10 (0.50) | PLA2G10PLA2G2AMEN1KMT2ALTB4R | |
| SCHEMBL18147989 | 0.68 | LTB4R (0.46) | LTB4RCYP1A2CYP2D6CYP3A4CYP2C9 | |
| SCHEMBL30634304 | 0.68 | PLA2G10 (0.50) | PLA2G10PLA2G2AMEN1KMT2ABRD4 | |
| SCHEMBL4060963 | 0.68 | ALDH1A1 (0.43) | PLA2G10PLA2G2APLAULTB4RBRD4 | |
| SCHEMBL25237748 | 0.67 | RNASEH1 (0.55) | PLA2G10PLA2G2AMEN1KMT2ALTB4R | |
| SCHEMBL4101721 | 0.67 | ALDH1A1 (0.56) | MEN1KMT2AALDH1A1HPGDHSD17B10 | |
| SCHEMBL4060972 | 0.66 | MPO (0.44) | PLA2G10PLA2G2APLAUMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016144797-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |
| WO-2016144792-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |