Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 2/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.31 |
| ▸ | LPO | P22079 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | STS | P08842 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20977770 | 0.84 | KDM4E (0.36) | KDM4EPOLBALDH1A1ELANEKMT2A | |
| SCHEMBL18054133 | 0.83 | ELANE (0.34) | KDM4EPOLBALDH1A1TSHRELANE | |
| SCHEMBL20224070 | 0.81 | ELANE (0.33) | ALDH1A1ELANENOTUMKMT2A | |
| SCHEMBL18053010 | 0.79 | KDM4E (0.34) | KDM4EPOLBALDH1A1ESR1CHRM1 | |
| SCHEMBL18052980 | 0.76 | NOTUM (0.54) | KDM4EPOLBALDH1A1ESR1NOTUM | |
| SCHEMBL20224079 | 0.74 | ALDH1A1 (0.30) | ALDH1A1 | |
| SCHEMBL18052970 | 0.74 | ALDH1A1 (0.39) | KDM4EPOLBALDH1A1TSHRELANE | |
| SCHEMBL18054331 | 0.74 | NPSR1 (0.39) | KDM4EPOLBALDH1A1TSHRELANE | |
| SCHEMBL13003012 | 0.73 | BCHE (0.45) | KDM4EALDH1A1ESR1TSHRTDP1 | |
| SCHEMBL20224081 | 0.72 | NOTUM (0.41) | ALDH1A1ELANENOTUMLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016138527-A1 | PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THEIR THERAPEUTICAL APPLICATIONS | NANTBIOSCIENCE, INC. (US) | 2016-09-01 | — | — | WO | disclosed |