Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | ESR1 | P03372 | 3/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.30 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.30 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.30 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.30 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20227289 | 0.85 | KDM4E (0.38) | KDM4EPOLBALDH1A1HTT | |
| SCHEMBL18054196 | 0.84 | PTGDR2 (0.33) | ALDH1A1LMNAMEN1MAPTKMT2A | |
| SCHEMBL20224077 | 0.82 | ALDH1A1 (0.30) | ALDH1A1SMYD3 | |
| SCHEMBL18052960 | 0.79 | KDM4E (0.35) | KDM4EPOLBALDH1A1ESR1CHRM1 | |
| SCHEMBL18054261 | 0.75 | TNF (0.37) | KDM4EPOLBALDH1A1LMNAMAPT | |
| SCHEMBL20224104 | 0.72 | LPO (0.35) | KDM4EALDH1A1TSHRLMNAMEN1 | |
| SCHEMBL20977760 | 0.72 | ALDH1A1 (0.36) | KDM4EALDH1A1TSHRLMNAMEN1 | |
| SCHEMBL20224079 | 0.70 | ALDH1A1 (0.30) | ALDH1A1 | |
| SCHEMBL20977770 | 0.69 | KDM4E (0.36) | KDM4EPOLBALDH1A1KMT2AHTT | |
| SCHEMBL18054133 | 0.68 | ELANE (0.34) | KDM4EPOLBALDH1A1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016138527-A1 | PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THEIR THERAPEUTICAL APPLICATIONS | NANTBIOSCIENCE, INC. (US) | 2016-09-01 | — | — | WO | disclosed |