SCHEMBL1806227

SCHEMBL1806227

O=C(O)[C@@H]1CCC[N+]1(C(=O)OCc1ccccc1)C(=O)OCc1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.45
NPC1 O15118 1/20 0.45
RAB9A P51151 1/20 0.45
CYP2C19 P33261 2/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2C9 P11712 1/20 0.44
ALDH1A1 P00352 5/20 0.44
GAA P10253 1/20 0.44
KMT2A Q03164 2/20 0.41
MAPK1 P28482 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
SLC6A2 P23975 1/20 0.41
SLC6A3 Q01959 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
TSHR P16473 2/20 0.41
FABP7 O15540 1/20 0.40
FABP5 Q01469 1/20 0.40
EPHX1 P07099 1/20 0.39
MEN1 O00255 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18281695 0.91 KMT2A (0.43) SMN1; SMN2NPC1RAB9ACYP2C19CYP3A4
SCHEMBL696626 0.90 CYP3A4 (0.40) SMN1; SMN2NPC1RAB9ACYP2C19CYP3A4
SCHEMBL6285067 0.84 CPB1 (0.44) SMN1; SMN2NPC1RAB9ACYP2C19CYP3A4
SCHEMBL15665799 0.83 ALDH1A1 (0.44) SMN1; SMN2NPC1RAB9ACYP2C19CYP3A4
SCHEMBL15665561 0.83 ALDH1A1 (0.44) SMN1; SMN2NPC1RAB9ACYP2C19CYP3A4
SCHEMBL3295119 0.81 CYP2C19 (0.45) SMN1; SMN2NPC1RAB9ACYP2C19CYP3A4
SCHEMBL14842868 0.80 CYP3A4 (0.47) SMN1; SMN2NPC1RAB9ACYP2C19CYP3A4
SCHEMBL8723700 0.80 ALDH1A1 (0.43) SMN1; SMN2NPC1RAB9ACYP2C19CYP3A4
SCHEMBL6634962 0.74 LMNA (0.46) ALDH1A1KMT2AMEN1
SCHEMBL489617 0.74 SMN1; SMN2 (0.42) SMN1; SMN2NPC1RAB9ACYP3A4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2496572-A1 BENZIMIDAZOLE-IMIDAZOLE DERIVATIVES Janssen R&D Ireland (IE) 2012-09-12 EP disclosed
WO-2011054834-A1 BENZIMIDAZOLE-IMIDAZOLE DERIVATIVES TIBOTEC PHARMACEUTICALS (IE) 2011-05-12 WO disclosed
EP-1866291-A1 ANTIBACTERIAL AMIDE MACROCYCLES VI AiCuris GmbH & Co. KG (DE) 2007-12-19 EP disclosed
WO-2006103009-A1 ANTIBACTERIAL AMIDE MACROCYCLES VI AICURIS GMBH & CO. KG (DE) 2006-10-05 WO disclosed