Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGER | Q15109 | 8/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | APAF1 | O14727 | 1/20 | 0.56 |
| ▸ | IDO1 | P14902 | 1/20 | 0.55 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.54 |
| ▸ | FDPS | P14324 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4070932 | 0.81 | AGER (0.67) | AGERMAPTMAPK1TSHRPOLB | |
| SCHEMBL30719991 | 0.80 | AGER (0.65) | AGERMAPTMAPK1TSHRPOLB | |
| SCHEMBL25297849 | 0.80 | AGER (0.65) | AGERMAPTMAPK1TSHRPOLB | |
| SCHEMBL6791275 | 0.79 | GGPS1 (0.64) | AGERMAPTMAPK1TSHRPOLB | |
| SCHEMBL16603995 | 0.78 | AGER (1.00) | AGERMAPTMAPK1TSHRPOLB | |
| SCHEMBL6839525 | 0.78 | P2RX7 (0.69) | AGERMAPTMAPK1TSHRPOLB | |
| SCHEMBL16603982 | 0.77 | AGER (1.00) | AGERMAPTMAPK1TSHRPOLB | |
| SCHEMBL16603976 | 0.77 | IDO1 (0.74) | AGERMAPTMAPK1TSHRPOLB | |
| SCHEMBL16603963 | 0.77 | BACE1 (0.65) | AGERMAPTMAPK1TSHRPOLB | |
| SCHEMBL6176569 | 0.76 | APAF1 (0.68) | AGERMAPTMAPK1TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160263125-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | NEW YORK UNIVERSITY | 2016-09-15 | — | — | US | disclosed |
| US-20160263125-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | NEW YORK UNIVERSITY | 2016-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160263125-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | AGER, IAPP, GPR119 | AGER 1/4885MAPT 1914/4885MAPK1 1066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.