Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.46 |
| ▸ | VNN1 | O95497 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 2/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | USP10 | Q14694 | 1/20 | 0.43 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.43 |
| ▸ | USP13 | Q92995 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15528783 | 0.87 | KMT2A (0.56) | KDM4EALDH1A1HPGDMAPTP4HTM | |
| SCHEMBL15529175 | 0.83 | MAPT (0.57) | KDM4EALDH1A1HPGDMAPTP4HTM | |
| SCHEMBL18070922 | 0.80 | KDM4E (0.62) | KDM4EALDH1A1MAPTKMT2ARPS6KB1 | |
| SCHEMBL18048981 | 0.79 | KDR (0.56) | KDM4EALDH1A1MAPTP4HTMVNN1 | |
| SCHEMBL18048969 | 0.79 | VNN1 (0.51) | KDM4EALDH1A1HPGDMAPTP4HTM | |
| SCHEMBL18071004 | 0.78 | PLAU (0.38) | KDM4EALDH1A1HPGDMAPTP4HTM | |
| SCHEMBL18048963 | 0.77 | L3MBTL1 (0.53) | ALDH1A1MAPTVNN1KMT2AL3MBTL1 | |
| SCHEMBL18049798 | 0.76 | VNN1 (0.46) | ALDH1A1HPGDMAPTVNN1KMT2A | |
| SCHEMBL18048975 | 0.76 | NAMPT (0.47) | ALDH1A1MAPTP4HTMRPS6KB1AURKA | |
| SCHEMBL18048998 | 0.76 | ALDH1A1 (0.57) | ALDH1A1RPS6KB1AURKAPDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016144792-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |
| WO-2016144797-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |