Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | GAK | O14976 | 1/20 | 0.34 |
| ▸ | CDC25C | P30307 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7466490 | 0.87 | HTT (0.53) | ALDH1A1SMN1; SMN2HTTPKMCYP1A2 | |
| SCHEMBL8419857 | 0.76 | CA12 (0.47) | ALDH1A1CYP1A2CYP3A4GAAMAPT | |
| Hydrochloric Acid SCHEMBL9793009 | 0.75 | CA12 (0.46) | ALDH1A1CYP1A2CYP3A4GAAMAPT | |
| SCHEMBL14831731 | 0.75 | MAPT (0.47) | ALDH1A1SMN1; SMN2HTTGAKGAA | |
| SCHEMBL143046 | 0.75 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2NSD2NCOA1NCOA3 | |
| Hydrochloric Acid SCHEMBL14833948 | 0.74 | GAA (0.46) | ALDH1A1SMN1; SMN2HTTGAKGAA | |
| SCHEMBL7469423 | 0.73 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL13981885 | 0.73 | PDCD1 (0.45) | ALDH1A1SMN1; SMN2HTTPKMCYP3A4 | |
| SCHEMBL7470964 | 0.72 | HTT (0.53) | ALDH1A1SMN1; SMN2HTTPKMCYP1A2 | |
| SCHEMBL14846133 | 0.72 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2GAKGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2760825-B1 | AZO MEDIATORS | HOFFMANN LA ROCHE (CH) | 2016-09-14 | — | — | EP | disclosed |