Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.35 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.34 |
| ▸ | IDO1 | P14902 | 3/20 | 0.34 |
| ▸ | TDO2 | P48775 | 3/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16519796 | 1.00 | MERTK (0.36) | MERTKCYP1A2CYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL1808792 | 0.83 | CYP1A2 (0.39) | MERTKCYP1A2CYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL12620407 | 0.81 | DAPK1 (0.46) | MERTKSYKKCNH2MAPK3MAPK1 | |
| SCHEMBL12653247 | 0.79 | ALDH1A1 (0.46) | MERTKCYP1A2CYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL1806946 | 0.79 | CYP1A2 (0.38) | MERTKCYP1A2CYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL12653151 | 0.79 | CYP1A2 (0.38) | MERTKCYP1A2CYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL1803527 | 0.76 | LTA4H (0.41) | CYP1A2CYP2D6CYP2C19SMN1; SMN2HIF1A | |
| SCHEMBL12620446 | 0.76 | MERTK (0.36) | MERTKCYP1A2CYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL12620422 | 0.75 | HTR2C (0.40) | CYP1A2CYP2D6CYP2C19SMN1; SMN2HIF1A | |
| SCHEMBL1807618 | 0.75 | PRMT5 (0.40) | CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895573-B2 | Phenoxy-substituted pyrimidines as opioid receptor modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2014-11-25 | — | — | US | disclosed |
| US-8895573-B2 | Phenoxy-substituted pyrimidines as opioid receptor modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2014-11-25 | — | — | US | disclosed |
| US-20140066422-A1 | PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2014-03-06 | — | — | US | disclosed |
| US-20140066422-A1 | PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2014-03-06 | — | — | US | disclosed |
| US-8394809-B2 | Phenoxy-substituted pyrimidines as opioid receptor modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2013-03-12 | — | — | US | disclosed |
| US-8394809-B2 | Phenoxy-substituted pyrimidines as opioid receptor modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2013-03-12 | — | — | US | disclosed |
| EP-2493863-A1 | PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011053701-A1 | PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | WO | disclosed |
| WO-2011053701-A1 | PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | WO | disclosed |
| US-20110105455-A1 | PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2011-05-05 | — | — | US | disclosed |
| US-20110105455-A1 | PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140066422-A1 | PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS | OPRK1, OPRL1, OPRM1 | MERTK 1738/4885CYP1A2 334/4885CYP2D6 280/4885 |
| US-20110105455-A1 | PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS | OPRK1, OPRL1, OPRM1 | MERTK 1738/4885CYP1A2 334/4885CYP2D6 280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.