SCHEMBL388034

SCHEMBL388034

COC(=O)c1sccc1S(=O)(=O)Cl

nearest known ligand 0.55

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.55
TP53 P04637 1/20 0.55
EDNRA P25101 3/20 0.52
LMNA P02545 4/20 0.51
THRB P10828 1/20 0.51
KMT2A Q03164 3/20 0.49
POLB P06746 1/20 0.48
HPGD P15428 2/20 0.48
TSHR P16473 1/20 0.48
NPC1 O15118 1/20 0.47
MEN1 O00255 1/20 0.46
CYP1A2 P05177 1/20 0.46
KCNH2 Q12809 1/20 0.46
PPARG P37231 1/20 0.45
PPARD Q03181 1/20 0.45
PPARA Q07869 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11471141 0.84 EDNRA (0.52) MAPTTP53EDNRALMNATHRB
SCHEMBL12319426 0.84 EDNRA (0.52) MAPTTP53EDNRALMNATHRB
SCHEMBL4095819 0.83 LMNA (0.44) MAPTTP53EDNRALMNATHRB
SCHEMBL31607236 0.83 EDNRA (0.51) MAPTTP53EDNRALMNATHRB
SCHEMBL4358291 0.83 CA1 (0.51) MAPTTP53EDNRALMNATHRB
SCHEMBL8973307 0.82 PKM (0.45) MAPTTP53EDNRALMNAKMT2A
SCHEMBL11469582 0.81 EDNRA (0.56) MAPTTP53EDNRALMNATHRB
SCHEMBL27500761 0.80 MAPT (0.53) MAPTTP53LMNAKMT2AHPGD
SCHEMBL23569071 0.80 EDNRA (0.49) MAPTTP53EDNRALMNATHRB
SCHEMBL14443239 0.80 EDNRA (0.50) MAPTTP53EDNRALMNATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 451 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116693498-B Method for synthesizing 5-chloro-3- (chlorosulfonyl) -2-thiophenecarboxylic acid methyl ester by utilizing continuous flow reaction 湖北广济医药科技有限公司 2024-01-30 CN claimed
CN-116693498-A Method for synthesizing 5-chloro-3- (chlorosulfonyl) -2-thiophenecarboxylic acid methyl ester by utilizing continuous flow reaction 湖北广济医药科技有限公司 2023-09-05 CN claimed
US-12612384-B2 Heterocyclic CYP4A inhibitor compounds and compositions thereof MBD Co., Ltd. (KR) 2026-04-28 US disclosed
EP-3745105-B1 TEMPERATURE DETECTION LABEL AND ARTICLE MANAGEMENT DEVICE USING SAME HITACHI LTD (JP) 2025-08-27 EP disclosed
EP-3728194-B1 QUINOLINE SULFONAMIDE COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS OTAGO INNOVATION LTD (NZ) 2025-06-04 EP disclosed
CN-115872994-B Small molecule targeting MAGI2 GK structural domain and application thereof 中国人民解放军陆军军医大学 2025-05-16 CN disclosed
US-20250144094-A1 THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF ERASCA, INC. 2025-05-08 US disclosed
US-20240400247-A1 TEMPERATURE INDICATOR MANUFACTURING SYSTEM AND TEMPERATURE INDICATOR MANUFACTURING METHOD HITACHI INDUSTRIAL EQUIPMENT SYSTEMS CO., LTD. (JP) 2024-12-05 US disclosed
EP-3986879-B1 FUSED 1,2-THIAZOLES AND 1,2-THIAZINES WHICH ACT AS NLRP3 MODULATORS AC IMMUNE SA (CH) 2024-10-02 EP disclosed
EP-4433059-A1 THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF Erasca, Inc. (US) 2024-09-25 EP disclosed
EP-4431889-A1 TEMPERATURE INDICATOR MANUFACTURING SYSTEM AND TEMPERATURE INDICATOR MANUFACTURING METHOD Hitachi Industrial Equipment Systems Co., Ltd. (JP) 2024-09-18 EP disclosed
US-4230873-A Thiophene derivatives HOFFMANN-LA ROCHE INC. (US) 1980-10-28 US disclosed
US-4224445-A ANTIINFLAMMATORY, ANALGESIC, ANTIRHEUMATIC HOFFMANN-LA ROCHE INC. (US) 1980-09-23 US disclosed
US-4177193-A ALKOXYCARBONYL, ALKYLAMINOSULFONYL-SUBSTITUTED THIOPHENE INTERMEDIATES FOR THE 4-HYDROXY-N-SUBSTITUTED-2H-THIENO(2,3-E)-1,2-THIAZINE-3-CARBOXAMIDE-1,1 -DIOXIDES; ANTIINFLAMMATORY, ANALGESIC HOFFMAN-LA ROCHE INC. (US) 1979-12-04 US disclosed
US-4175085-A ANTIINFLAMMATORY, ANALGESIC, ANTIRHEUMATIC HOFFMANN-LA ROCHE INC. (US) 1979-11-20 US disclosed
US-4143050-A MANUFACTURE OF 3-HALOSULFONYLTHIOPHENE-CARBOXYLIC ACID COMPOUNDS BASF AKTIENGESELLSCHAFT (DE) 1979-03-06 US disclosed
US-4134898-A ANTIINFLAMMATORY, ANALGESIC, ANTIRHEUMATIC HOFFMANN-LA ROCHE INC. (US) 1979-01-16 US disclosed
US-4090020-A ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIRHEUMATIC AGENTS HOFFMANN-LA ROCHE INC. (US) 1978-05-16 US disclosed
US-4076709-A ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIRHEUMATIC AGENTS HOFFMANN-LA ROCHE INC. (US) 1978-02-28 US disclosed
US-4028373-A ARTIFICIAL SWEETNERS BASF AKTIENGESELLSCHAFT (DT) 1977-06-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250144094-A1 THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF ULK1, ULK2, ULK3 MAPT 710/4885TP53 207/4885EDNRA 4571/4885
US-12612384-B2 Heterocyclic CYP4A inhibitor compounds and compositions thereof CYP4A11, CYP4B1, CYP4A22 MAPT 2797/4885TP53 2055/4885EDNRA 2740/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.