Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3622678 | 0.88 | EPHX1 (0.40) | EPHX1SMN1; SMN2EPHX2USP2ALDH1A1 | |
| SCHEMBL3619623 | 0.88 | MAPT (0.41) | SMN1; SMN2ALDH1A1CYP2D6CYP2C9POLB | |
| SCHEMBL14430917 | 0.86 | EPHX1 (0.36) | EPHX1USP2ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL3616921 | 0.81 | EPHX1 (0.38) | EPHX1USP2ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL14430918 | 0.80 | THRB (0.36) | EPHX1ALDH1A1POLBGAATSHR | |
| SCHEMBL30108302 | 0.77 | POLB (0.38) | SMN1; SMN2USP2ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL711832 | 0.71 | ATM (0.34) | SMN1; SMN2CYP1A2CYP2C9TSHRCYP2C19 | |
| SCHEMBL9610 | 0.70 | ATM (0.33) | SMN1; SMN2ALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL31597078 | 0.69 | EPHX1 (0.38) | EPHX1SMN1; SMN2USP2ALDH1A1CYP1A2 | |
| SCHEMBL3613755 | 0.68 | USP2 (0.39) | EPHX1SMN1; SMN2USP2ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11332478-B2 | Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol | H. LUNDBECK A/S (DK) | 2022-05-17 | — | — | US | disclosed |
| US-20200223865-A1 | MANUFACTURE OF 4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDIN-3-OL | H. LUNDBECK A/S (DK) | 2020-07-16 | — | — | US | disclosed |
| US-10626123-B2 | Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol | H. LUNDBECK A/S (DK) | 2020-04-21 | — | — | US | disclosed |
| EP-3274331-B1 | MANUFACTURE OF 4,5,6,7-TETRAHYDROISOZAXOLO[5,4-C]PYRIDIN-3-OL | H LUNDBECK AS (DK) | 2020-02-26 | — | — | EP | disclosed |
| US-20180065984-A1 | Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol | H. LUNDBECK A/S (DK) | 2018-03-08 | — | — | US | disclosed |
| EP-3274331-A1 | MANUFACTURE OF 4,5,6,7-TETRAHYDROISOZAXOLO[5,4-C]PYRIDIN-3-OL | H. Lundbeck A/S (DK) | 2018-01-31 | — | — | EP | disclosed |
| WO-2016150953-A1 | MANUFACTURE OF 4,5,6,7-TETRAHYDROISOZAXOLO[5,4-C]PYRIDIN-3-OL | H. LUNDBECK A/S (DK) | 2016-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11332478-B2 | Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol | GABRP, GABRD, GABRA5 | EPHX1 663/4885SMN1; SMN2 2725/4885EPHX2 452/4885 |
| US-10626123-B2 | Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol | GABRP, GABRA5, GABRD | EPHX1 641/4885SMN1; SMN2 2707/4885EPHX2 440/4885 |
| US-20200223865-A1 | MANUFACTURE OF 4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDIN-3-OL | GABRP, GABRD, GABRA5 | EPHX1 663/4885SMN1; SMN2 2725/4885EPHX2 452/4885 |
| US-20180065984-A1 | Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol | GABRP, GABRA5, GABRD | EPHX1 641/4885SMN1; SMN2 2707/4885EPHX2 440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.