Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 2/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18095949 | 0.90 | CYP1A2 (0.46) | TSHRGAAMGAMSIMGAM2 | |
| SCHEMBL3496977 | 0.81 | GAA (0.52) | GAAMGAMSIMGAM2CA12 | |
| SCHEMBL5573011 | 0.78 | CYP1A2 (0.46) | TSHRGAAMGAMSIMGAM2 | |
| SCHEMBL20379769 | 0.77 | CA14 (0.38) | GAAMGAMSIMGAM2ALOX5 | |
| SCHEMBL27705199 | 0.77 | LMNA (0.47) | TSHRCYP1A2KDM5AKDM4CKMT2A | |
| SCHEMBL10653733 | 0.74 | GAA (0.48) | TSHRGAAMGAMSIMGAM2 | |
| SCHEMBL7368645 | 0.74 | TSHR (0.44) | TSHRCA12CA1CA2KMT2A | |
| SCHEMBL20165511 | 0.73 | AKR1B1 (0.47) | TSHRCA12CA1CA9KDM5A | |
| SCHEMBL1935858 | 0.73 | CA12 (0.43) | TSHRGAAMGAMSIMGAM2 | |
| SCHEMBL7456183 | 0.73 | CA14 (0.40) | GAAMGAMSIMGAM2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11332478-B2 | Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol | H. LUNDBECK A/S (DK) | 2022-05-17 | — | — | US | disclosed |
| CN-107428776-B | Production of 4,5,6, 7-tetrahydroisoxazolo [5,4-c ] pyridin-3-ol | H.隆德贝克有限公司 | 2020-10-23 | — | — | CN | disclosed |
| US-20200223865-A1 | MANUFACTURE OF 4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDIN-3-OL | H. LUNDBECK A/S (DK) | 2020-07-16 | — | — | US | disclosed |
| US-10626123-B2 | Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol | H. LUNDBECK A/S (DK) | 2020-04-21 | — | — | US | disclosed |
| EP-3274331-B1 | MANUFACTURE OF 4,5,6,7-TETRAHYDROISOZAXOLO[5,4-C]PYRIDIN-3-OL | H LUNDBECK AS (DK) | 2020-02-26 | — | — | EP | disclosed |
| US-20180065984-A1 | Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol | H. LUNDBECK A/S (DK) | 2018-03-08 | — | — | US | disclosed |
| EP-3274331-A1 | MANUFACTURE OF 4,5,6,7-TETRAHYDROISOZAXOLO[5,4-C]PYRIDIN-3-OL | H. Lundbeck A/S (DK) | 2018-01-31 | — | — | EP | disclosed |
| WO-2016150953-A1 | MANUFACTURE OF 4,5,6,7-TETRAHYDROISOZAXOLO[5,4-C]PYRIDIN-3-OL | H. LUNDBECK A/S (DK) | 2016-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11332478-B2 | Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol | GABRP, GABRD, GABRA5 | TSHR 1650/4885GAA 4307/4885MGAM 4684/4885 |
| US-10626123-B2 | Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol | GABRP, GABRA5, GABRD | TSHR 1635/4885GAA 4320/4885MGAM 4694/4885 |
| US-20200223865-A1 | MANUFACTURE OF 4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDIN-3-OL | GABRP, GABRD, GABRA5 | TSHR 1650/4885GAA 4307/4885MGAM 4684/4885 |
| US-20180065984-A1 | Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol | GABRP, GABRA5, GABRD | TSHR 1635/4885GAA 4320/4885MGAM 4694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.