Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | CASP1 | P29466 | 1/20 | 0.74 |
| ▸ | RAB9A | P51151 | 9/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | MITF | O75030 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 8/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | HPGD | P15428 | 5/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 4/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4879301 | 1.00 | ALOX15 (0.74) | ALOX15TSHRCASP1RAB9AKMT2A | |
| SCHEMBL14140425 | 0.87 | ALOX15 (0.54) | ALOX15TSHRCASP1RAB9AKMT2A | |
| SCHEMBL13600370 | 0.87 | RAB9A (0.67) | ALOX15TSHRCASP1RAB9AKMT2A | |
| SCHEMBL75219 | 0.86 | ALOX15 (1.00) | ALOX15TSHRCASP1RAB9AKMT2A | |
| SCHEMBL10726923 | 0.86 | ALOX15 (1.00) | ALOX15TSHRCASP1RAB9AKMT2A | |
| SCHEMBL12573259 | 0.86 | HSD17B1 (0.57) | ALOX15TSHRCASP1RAB9AKMT2A | |
| SCHEMBL12573258 | 0.86 | APP (0.64) | ALOX15TSHRCASP1RAB9AKMT2A | |
| SCHEMBL620114 | 0.84 | ALOX15 (0.51) | ALOX15TSHRCASP1RAB9AKMT2A | |
| SCHEMBL1267325 | 0.84 | ALOX15 (0.96) | ALOX15TSHRCASP1RAB9AKMT2A | |
| SCHEMBL2684521 | 0.84 | ALOX15 (0.96) | ALOX15TSHRCASP1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030175813-A1 | Microplate thermal shift assay for ligand development using 5- (4\"-dimethylaminophenyl) -2- (4' -phenyl) oxazole derivative fluorescent dyes | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2003-09-18 | — | — | US | claimed |
| US-6569631-B1 | Measuring binding affinity of different molecules for a protein which is capable of unfolding due to temperature variations; use in high throughput drug screening | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2003-05-27 | — | — | US | claimed |
| US-20210063405-A1 | METHODS FOR DYE SELECTION FOR PROTEIN MELT TEMPERATURE DETERMINATIONS | Life Technologies Corporation | 2021-03-04 | — | — | US | disclosed |
| US-10866245-B2 | Methods for dye selection for protein melt temperature determinations | Life Technologies Corporation (US) | 2020-12-15 | — | — | US | disclosed |
| US-20180348230-A1 | METHODS FOR DYE SELECTION FOR PROTEIN MELT TEMPERATURE DETERMINATIONS | Life Technologies Corporation | 2018-12-06 | — | — | US | disclosed |
| US-10024863-B2 | Methods for dye selection for protein melt temperature determinations | Life Technologies Corporation (US) | 2018-07-17 | — | — | US | disclosed |
| US-20140315190-A1 | METHODS FOR DYE SELECTION FOR PROTEIN MELT TEMPERATURE DETERMINATIONS | Life Technologies Corporation | 2014-10-23 | — | — | US | disclosed |
| WO-2011051484-A1 | FLUORESCENCE DYES | GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN STIFTUNG ÖFFENLICHEN RECHTS (DE) | 2011-05-05 | — | — | WO | disclosed |
| US-20100025482-A1 | COMPOSITION INCLUDING AN ITEM AND AN ENCODED OPTICAL IDENTIFICATION ELEMENT THAT IS PHYSICALLY ASSOCIATED WITH THE ITEM | ILLUMINA CORPORATION (US) | 2010-02-04 | — | — | US | disclosed |
| US-7623624-B2 | Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction | ILLUMINA, INC. (US) | 2009-11-24 | — | — | US | disclosed |
| US-20070121181-A1 | Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction | CYVERA CORPORATION | 2007-05-31 | — | — | US | disclosed |
| EP-1552475-A1 | CHEMICAL SYNTHESIS USING DIFFRACTION GRATING-BASED ENCODED OPTICAL ELEMENTS | Cyvera Corporation (US) | 2005-07-13 | — | — | EP | disclosed |
| US-20040130761-A1 | Chemical synthesis using diffraction grating-based encoded optical elements | ILLUMINA, INC. | 2004-07-08 | — | — | US | disclosed |
| WO-2004025561-A1 | CHEMICAL SYNTHESIS USING DIFFRACTION GRATING-BASED ENCODED OPTICAL ELEMENTS | CYVERA CORPORATION (US) | 2004-03-25 | — | — | WO | disclosed |
| US-20030175813-A1 | Microplate thermal shift assay for ligand development using 5- (4\"-dimethylaminophenyl) -2- (4' -phenyl) oxazole derivative fluorescent dyes | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2003-09-18 | — | — | US | disclosed |
| US-20030175813-A1 | Microplate thermal shift assay for ligand development using 5- (4\"-dimethylaminophenyl) -2- (4' -phenyl) oxazole derivative fluorescent dyes | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2003-09-18 | — | — | US | disclosed |
| US-6569631-B1 | Measuring binding affinity of different molecules for a protein which is capable of unfolding due to temperature variations; use in high throughput drug screening | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2003-05-27 | — | — | US | disclosed |
| US-6569631-B1 | Measuring binding affinity of different molecules for a protein which is capable of unfolding due to temperature variations; use in high throughput drug screening | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2003-05-27 | — | — | US | disclosed |
| US-20020168686-A1 | High throughput method for functionally classifying proteins identified using a genomics approach | Life Technologies Corporation | 2002-11-14 | — | — | US | disclosed |
| US-20010003648-A1 | HIGH THROUGHPUT METHOD FOR FUNCTIONALLY CLASSIFYING PROTEINS IDENTIFIED USING A GENOMICS APPROACH | 3-DIMENSIONAL PHARMACEUTICALS INC. | 2001-06-14 | — | — | US | disclosed |