Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 8/20 | 0.48 |
| ▸ | NPC1 | O15118 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | STAT1 | P42224 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11516136 | 0.85 | TSHR (0.62) | ALOX15TSHRCASP1RAB9ANPC1 | |
| SCHEMBL13600370 | 0.84 | RAB9A (0.67) | ALOX15TSHRCASP1RAB9ANPC1 | |
| SCHEMBL14140425 | 0.84 | ALOX15 (0.54) | ALOX15TSHRCASP1RAB9ANPC1 | |
| SCHEMBL1809702 | 0.84 | ALOX15 (0.74) | ALOX15TSHRCASP1RAB9ANPC1 | |
| SCHEMBL4879301 | 0.84 | ALOX15 (0.74) | ALOX15TSHRCASP1RAB9ANPC1 | |
| SCHEMBL12573258 | 0.83 | APP (0.64) | ALOX15TSHRCASP1RAB9ANPC1 | |
| SCHEMBL12573259 | 0.83 | HSD17B1 (0.57) | ALOX15TSHRCASP1RAB9ANPC1 | |
| SCHEMBL13662152 | 0.81 | TSHR (0.50) | ALOX15TSHRCASP1RAB9ANPC1 | |
| SCHEMBL13657992 | 0.81 | PTPN1 (0.53) | ALOX15TSHRCASP1RAB9ANPC1 | |
| SCHEMBL24158197 | 0.79 | CYP2A6 (0.54) | ALOX15TSHRCASP1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170073359-A1 | Optically-Detectable Enzyme Substrates and Their Method of Use | MOLECULAR PROBES, INC. | 2017-03-16 | — | — | US | disclosed |
| US-20160139135-A1 | Optically-Detectable Enzyme Substrates and Their Method of Use | LIFE TECHNOLOGIES CORP (US) | 2016-05-19 | — | — | US | disclosed |
| US-8865891-B2 | Optically-detectable enzyme substrates and their method of use | Life Technologies Corporation (US) | 2014-10-21 | — | — | US | disclosed |
| US-20130090470-A1 | OPTICALLY-DETECTABLE ENZYME SUBSTRATES AND THEIR METHOD OF USE | Life Technologies Corporation (US) | 2013-04-11 | — | — | US | disclosed |
| US-8318450-B2 | Optically-detectable enzyme substrates and their method of use | Life Technologies Corporation (US) | 2012-11-27 | — | — | US | disclosed |
| US-20120040380-A1 | OPTICALLY-DETECTABLE ENZYME SUBSTRATES AND THEIR METHOD OF USE | Life Technologies Corporation (US) | 2012-02-16 | — | — | US | disclosed |
| US-20090047692-A1 | OPTICALLY-DETECTABLE ENZYME SUBSTRATES AND THEIR METHOD OF USE | INVITROGEN CORPORATION (US) | 2009-02-19 | — | — | US | disclosed |
| EP-1711504-A2 | DERIVATIVES OF CEPHALOSPORIN AND CLAVULANIC ACID FOR DETECTING BETA-LACTAMASE IN A SAMPLE | Molecular Probes Inc. (US) | 2006-10-18 | — | — | EP | disclosed |
| WO-2005071096-A9 | DERIVATIVES OF CEPHALOSPORIN AND CLAVULANIC ACID FOR DETECTING BETA-LACAMASE IN A SAMPLE | — | 2006-02-02 | — | — | WO | disclosed |
| US-20050227309-A1 | Optically-detectable enzyme substrates and their method of use | MOLECULAR PROBES, INC. | 2005-10-13 | — | — | US | disclosed |
| WO-2005071096-A2 | DERIVATIVES OF CEPHALOSPORIN AND CLAVULANIC ACID FOR DETECTING BETA-LACAMASE IN A SAMPLE | MOLECULAR PROBES, INC. (US) | 2005-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160139135-A1 | Optically-Detectable Enzyme Substrates and Their Method of Use | MGAM, LCT, GAA | ALOX15 1181/4885TSHR 3175/4885CASP1 4653/4885 |
| US-20170073359-A1 | Optically-Detectable Enzyme Substrates and Their Method of Use | MGAM, LCT, GAA | ALOX15 1181/4885TSHR 3175/4885CASP1 4653/4885 |
| US-20130090470-A1 | OPTICALLY-DETECTABLE ENZYME SUBSTRATES AND THEIR METHOD OF USE | MGAM, LCT, GAA | ALOX15 1181/4885TSHR 3175/4885CASP1 4653/4885 |
| US-20090047692-A1 | OPTICALLY-DETECTABLE ENZYME SUBSTRATES AND THEIR METHOD OF USE | MGAM, LCT, GAA | ALOX15 1181/4885TSHR 3175/4885CASP1 4653/4885 |
| US-20050227309-A1 | Optically-detectable enzyme substrates and their method of use | MGAM, LCT, GAA | ALOX15 1181/4885TSHR 3175/4885CASP1 4653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.