Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13563916 | 0.81 | CYP2C9 (0.46) | KDM4EALDH1A1USP2HSP90AB1MEN1 | |
| SCHEMBL10274452 | 0.79 | KDM4E (0.40) | KDM4EALDH1A1USP2HSP90AB1HTT | |
| SCHEMBL6949283 | 0.78 | GABRA5 (0.39) | KDM4EALDH1A1HSD17B10MAPTPOLB | |
| SCHEMBL10137877 | 0.76 | CPB2 (0.52) | KDM4EALDH1A1USP2KDM5B | |
| SCHEMBL14551478 | 0.72 | CPB2 (0.39) | KDM4EALDH1A1USP2MEN1KMT2A | |
| SCHEMBL7256301 | 0.72 | FGFR1 (0.38) | KDM4EALDH1A1USP2HSP90AB1HTT | |
| SCHEMBL31006001 | 0.71 | KDM4E (0.37) | KDM4EALDH1A1USP2MEN1KMT2A | |
| SCHEMBL19402101 | 0.71 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2AMAPTGAA | |
| SCHEMBL8865798 | 0.71 | CDK5 (0.54) | KDM4EALDH1A1KMT2AKDM5B | |
| SCHEMBL8865591 | 0.70 | CDK5 (0.42) | ALDH1A1USP2KDM5BSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2548872-B1 | CYCLOPROPANECARBOXYLIC ACID DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2016-09-28 | — | — | EP | disclosed |