SCHEMBL181009

SCHEMBL181009

O=C(CI)NCCCCCC(=O)ON1C(=O)CCC1=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.41
HPGD P15428 1/20 0.41
HTT P42858 1/20 0.41
HDAC3 O15379 2/20 0.35
HDAC4 P56524 2/20 0.35
HDAC1 Q13547 2/20 0.35
HDAC7 Q8WUI4 2/20 0.35
HDAC2 Q92769 2/20 0.35
HDAC10 Q969S8 2/20 0.35
HDAC11 Q96DB2 2/20 0.35
HDAC8 Q9BY41 2/20 0.35
HDAC6 Q9UBN7 2/20 0.35
HDAC9 Q9UKV0 2/20 0.35
HDAC5 Q9UQL6 2/20 0.35
NAMPT P43490 1/20 0.33
KMT2A Q03164 2/20 0.33
ALDH1A1 P00352 2/20 0.33
MEN1 O00255 1/20 0.33
FAAH O00519 1/20 0.33
ABHD16A O95870 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1255461 1.00 SMN1; SMN2 (0.41) SMN1; SMN2HPGDHTTHDAC3HDAC4
SCHEMBL2734922 0.99 SMN1; SMN2 (0.39) SMN1; SMN2HPGDHTTHDAC3HDAC4
SCHEMBL180975 0.97 SMN1; SMN2 (0.45) SMN1; SMN2HPGDHTTHDAC3HDAC4
SCHEMBL8663263 0.94 SMN1; SMN2 (0.37) SMN1; SMN2HPGDHTTLMNA
SCHEMBL26382038 0.90 SMN1; SMN2 (0.50) SMN1; SMN2HPGDHTTHDAC3HDAC4
SCHEMBL17767812 0.90 SMN1; SMN2 (0.50) SMN1; SMN2HPGDHTTHDAC3HDAC4
SCHEMBL17767809 0.90 SMN1; SMN2 (0.50) SMN1; SMN2HPGDHTTHDAC3HDAC4
SCHEMBL20999873 0.90 SMN1; SMN2 (0.50) SMN1; SMN2HPGDHTTHDAC3HDAC4
SCHEMBL17168743 0.90 SMN1; SMN2 (0.50) SMN1; SMN2HPGDHTTHDAC3HDAC4
SCHEMBL31128140 0.89 EPHX2 (0.45) SMN1; SMN2KMT2AEPHX2CASP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1371 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240293524-A1 MULTIPLE FUNCTIONALIZED noMV CONJUGATES GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2024-09-05 US claimed
US-11712423-B2 Methods and compositions for modifying mucous membranes ABBOTT NICHOLAS L (US) 2023-08-01 US claimed
CN-116068167-A Separation and detection method of extracellular biomacromolecule 厦门福流生物科技有限公司 2023-05-05 CN claimed
US-20230137914-A1 nOMV-ANTIGEN CONJUGATED COMPOUNDS AND USE THEREOF GLAXOSMITHKLINE BIOLOGICALS, S.A. (BE) 2023-05-04 US claimed
US-20220008529-A1 MULTI-FUNCTIONALIZED noMV CONJUGATES GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2022-01-13 US claimed
EP-3799883-A1 NOMV-ANTIGEN CONJUGATED COMPOUNDS AND USE THEREOF GlaxoSmithKline Biologicals S.A. (BE) 2021-04-07 EP claimed
EP-3664837-A1 MULTI-FUNCTIONALIZED nOMV CONJUGATES GlaxoSmithKline Biologicals S.A. (BE) 2020-06-17 EP claimed
EP-3544637-A1 nOMV-ANTIGEN CONJUGATES AND USE THEREOF GlaxoSmithKline Biologicals S.A. (BE) 2019-10-02 EP claimed
WO-2019030271-A1 MULTI-FUNCTIONALIZED nOMV CONJUGATES GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2019-02-14 WO claimed
US-20180263927-A1 AFFINITY MEDICANT CONJUGATE AF CHEMICALS, LLC (US) 2018-09-20 US claimed
WO-2010111271-A1 ORALLY BIOAVAILABLE LIPID-BASED CONSTRUCTS SDG, INC. (AN OHIO CORPORATION) (US) 2010-09-30 WO claimed
CN-101790684-A Improvements in or relating to the preparation of conjugates INNOVA BIOSCIENCES LTD 2010-07-28 CN claimed
US-20100184184-A1 Production of Conjugates INNOVA BIOSCIENCES LIMITED (GB) 2010-07-22 US claimed
EP-2171457-A2 IMPROVEMENTS IN OR RELATING TO PRODUCTION OF CONJUGATES Innova Biosciences Limited (GB) 2010-04-07 EP claimed
US-20100080773-A1 Orally Bioavailable Lipid-Based Constructs SDG, INC. 2010-04-01 US claimed
WO-2008152424-A2 IMPROVEMENTS IN OR RELATING TO PRODUCTION OF CONJUGATES INNOVA BIOSCIENCES LIMITED (GB) 2008-12-18 WO claimed
US-20030148304-A1 Method for immobilisation KAROLINSKA INNOVATIONS AB (SE) 2003-08-07 US claimed
EP-1235937-A1 METHOD FOR IMMOBILISATION Karolinska Innovations AB (SE) 2002-09-04 EP claimed
US-6335176-B1 REAGENT IS SUCCINIMIDYL MOIETY LINKED TO KINASE SUBSTRATE; CAN BE LINKED TO FREE PRIMARY OR SECONDARY AMINE IN COMPOUND TO BE PHOSPHORYLATED PHARMACOPEIA, INC. 2002-01-01 US claimed
WO-2001042501-A1 METHOD FOR IMMOBILISATION KAROLINSKA INNOVATIONS AB (SE) 2001-06-14 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100080773-A1 Orally Bioavailable Lipid-Based Constructs FABP2, FABP1, LIPC SMN1; SMN2 3813/4885HPGD 1187/4885HTT 561/4885
US-20230137914-A1 nOMV-ANTIGEN CONJUGATED COMPOUNDS AND USE THEREOF VAPB, CD14, CHMP4B SMN1; SMN2 4307/4885HPGD 2833/4885HTT 3446/4885
US-20240293524-A1 MULTIPLE FUNCTIONALIZED noMV CONJUGATES CD14, VAPB, CHMP4B SMN1; SMN2 4171/4885HPGD 4105/4885HTT 3654/4885
US-20220008529-A1 MULTI-FUNCTIONALIZED noMV CONJUGATES CD14, CHMP4B, VAPB SMN1; SMN2 4243/4885HPGD 4079/4885HTT 3984/4885
US-20180263927-A1 AFFINITY MEDICANT CONJUGATE FCER2, HDGF, FCGR2A SMN1; SMN2 3267/4885HPGD 2885/4885HTT 3671/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.