SCHEMBL181031

SCHEMBL181031

C1=CN(c2ccccn2)c2ccccc2C1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GRIN1 Q05586 2/20 0.41
GRIN2B Q13224 2/20 0.41
GRIN2D O15399 1/20 0.41
GRIN3B O60391 1/20 0.41
GRIN2A Q12879 1/20 0.41
GRIN2C Q14957 1/20 0.41
GRIN3A Q8TCU5 1/20 0.41
PLD1 Q13393 1/20 0.38
CRBN Q96SW2 1/20 0.36
ALDH1A1 P00352 4/20 0.36
MAPT P10636 1/20 0.36
SMN1; SMN2 Q16637 3/20 0.35
KDM4E B2RXH2 2/20 0.34
LMNA P02545 1/20 0.34
GAA P10253 1/20 0.34
AVPR1A P37288 2/20 0.34
POLB P06746 1/20 0.33
EP300 Q09472 1/20 0.33
KAT2B Q92831 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30298041 0.82 GRIN2D (0.41) GRIN1GRIN2BGRIN2DGRIN3BGRIN2A
SCHEMBL1977844 0.76 CD274 (0.45) PLD1CRBNALDH1A1SMN1; SMN2KDM4E
SCHEMBL28286321 0.73 HPGD (0.39) ALDH1A1SMN1; SMN2LMNAGAAPOLB
SCHEMBL4071380 0.72 HPGD (0.38) ALDH1A1SMN1; SMN2LMNAGAAPOLB
SCHEMBL4148701 0.72 HPGD (0.38) ALDH1A1SMN1; SMN2LMNAGAAPOLB
SCHEMBL6024373 0.68 SMN1; SMN2 (0.47) GRIN1GRIN2BGRIN2DGRIN3BGRIN2A
SCHEMBL374979 0.66 ALDH1A1 (0.33) ALDH1A1MAPTSMN1; SMN2KDM4EPOLB
SCHEMBL29721478 0.66 ROCK1 (0.62) GRIN1GRIN2BGRIN2DGRIN3BGRIN2A
SCHEMBL6071629 0.66 ROCK1 (0.62) GRIN1GRIN2BGRIN2DGRIN3BGRIN2A
SCHEMBL1375450 0.65 NPC1 (0.35) ALDH1A1SMN1; SMN2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 194 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4388611-A1 IONIC BINDERS FOR SOLID STATE ELECTRODES Deakin University (AU) 2024-06-26 EP disclosed
CN-117941116-A Ionic binders for solid state electrodes 迪金大学 2024-04-26 CN disclosed
US-20240084308-A1 FIBROTIC TREATMENT MONASH UNIVERSITY (AU) 2024-03-14 US disclosed
US-20240034845-A1 POLYMER PARTICLES QUEENSLAND UNIVERSITY OF TECHNOLOGY (AU) 2024-02-01 US disclosed
EP-3384549-B1 SODIUM-ION ELECTROLYTE COMPOSITION UNIV DEAKIN (AU) 2024-01-17 EP disclosed
US-11834663-B2 Fibrotic treatment MONASH UNIVERSITY (AU) 2023-12-05 US disclosed
US-20230348674-A1 HYDROGELS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2023-11-02 US disclosed
EP-4225811-A1 POLYMER PARTICLES Queensland University Of Technology (AU) 2023-08-16 EP disclosed
US-20230216086-A1 ELECTROLYTES FOR TARGET ION TRANSPORT MONASH UNIVERSITY (AU) 2023-07-06 US disclosed
WO-2023121483-A1 IMMUNOSTIMULATORY COMPOSITIONS VICTORIA LINK LIMITED (NZ) 2023-06-29 WO disclosed
EP-2106260-A1 INSULIN SENSITISERS AND METHODS OF TREATMENT Verva Pharmaceuticals Ltd (AU) 2009-10-07 EP disclosed
CN-101547888-A Acetylenic compounds COMMW SCIENT IND RES ORG (AU) 2009-09-30 CN disclosed
WO-2009111830-A1 CONJUGATED UNSATURATED COMPOUNDS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2009-09-17 WO disclosed
WO-2009065169-A1 INSULIN-REGULATED AMINOPEPTIDASE (IRAP) INHIBITORS AND USES THEREOF HOWARD FLOREY INSTITUTE (AU) 2009-05-28 WO disclosed
EP-2059496-A1 ACETYLENIC COMPOUNDS Commonwealth Scientific and Industrial Research Organisation (AU) 2009-05-20 EP disclosed
WO-2009000049-A1 INTRINSICALLY CONDUCTING POLYMERS CRC SMARTPRINT PTY LTD (AU) 2008-12-31 WO disclosed
WO-2008089521-A1 INSULIN SENSITISERS AND METHODS OF TREATMENT VERVA PHARMACEUTICALS LTD (AU) 2008-07-31 WO disclosed
WO-2008046155-A1 METHODS FOR REGULATING GLUCOSE HOMEOSTASIS AND AGENTS THEREFOR DIA-B TECH LIMITED (AU) 2008-04-24 WO disclosed
WO-2008046156-A1 VESICULATED POLYMER PARTICLES THE UNIVERSITY OF SYDNEY (AU) 2008-04-24 WO disclosed
WO-2008031157-A1 ACETYLENIC COMPOUNDS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2008-03-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11834663-B2 Fibrotic treatment MMP1, ENPEP, RNPEP GRIN1 4457/4885GRIN2B 4518/4885GRIN2D 4855/4885
US-20230348674-A1 HYDROGELS PHYKPL, TST, PHOSPHO1 GRIN1 2118/4885GRIN2B 3032/4885GRIN2D 2830/4885
US-20240084308-A1 FIBROTIC TREATMENT MMP1, ENPEP, RNPEP GRIN1 4457/4885GRIN2B 4518/4885GRIN2D 4855/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.