Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | JUN | P05412 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.30 |
| ▸ | RELA | Q04206 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1549949 | 0.77 | KMT2A (0.38) | LMNAKMT2A | |
| SCHEMBL29099264 | 0.71 | LMNA (0.40) | LMNAKMT2A | |
| SCHEMBL5954700 | 0.69 | LMNA (0.42) | LMNAKMT2AJUNNFKB1NFKB2 | |
| SCHEMBL1550807 | 0.68 | LMNA (0.41) | LMNAKMT2AJUNNFKB1NFKB2 | |
| SCHEMBL30628250 | 0.67 | KMT2A (0.46) | LMNAKMT2A | |
| SCHEMBL31292247 | 0.65 | LMNA (0.43) | LMNAKMT2AJUNNFKB1NFKB2 | |
| SCHEMBL249487 | 0.62 | CNR2 (0.46) | LMNAKMT2A | |
| SCHEMBL1000276 | 0.61 | ALDH1A1 (0.40) | LMNAKMT2A | |
| SCHEMBL29559838 | 0.61 | JUN (0.39) | LMNAJUNNFKB1NFKB2RELA | |
| SCHEMBL155818 | 0.61 | JUN (0.39) | LMNAJUNNFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313407-B1 | cMET INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2016-10-05 | — | — | EP | disclosed |