Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MYC | P01106 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL991197 | 0.82 | ERCC5 (0.50) | NPC1RAB9AHPGDMYCALDH1A1 | |
| SCHEMBL28319862 | 0.78 | NPC1 (0.44) | NPC1RAB9AHPGDALDH1A1ERCC5 | |
| SCHEMBL7051581 | 0.75 | RAB9A (0.47) | NPC1RAB9AHPGDMYCALDH1A1 | |
| SCHEMBL28319996 | 0.75 | TSHR (0.50) | NPC1RAB9AALDH1A1HTTTDP1 | |
| SCHEMBL6099 | 0.74 | ALDH1A1 (0.56) | NPC1RAB9AHPGDMYCALDH1A1 | |
| SCHEMBL1558192 | 0.74 | ALDH1A1 (0.56) | NPC1RAB9AHPGDMYCALDH1A1 | |
| SCHEMBL28463115 | 0.74 | HPGD (0.40) | NPC1RAB9AHPGDALDH1A1ERCC5 | |
| SCHEMBL9091946 | 0.74 | CYP2C19 (0.50) | HPGDALDH1A1TDP1KMT2APOLB | |
| SCHEMBL27449528 | 0.73 | SMN1; SMN2 (0.42) | NPC1RAB9AHPGDMYCERCC5 | |
| SCHEMBL3870822 | 0.73 | ALDH1A1 (0.54) | NPC1RAB9AHPGDMYCALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11180748-B2 | Reagents and methods for esterification | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2021-11-23 | — | — | US | disclosed |
| US-20200032238-A1 | Reagents and Methods for Esterification | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2020-01-30 | — | — | US | disclosed |
| US-10428323-B2 | Reagents and methods for esterification | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2019-10-01 | — | — | US | disclosed |
| US-20180037881-A1 | Reagents and Methods for Esterification | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-02-08 | — | — | US | disclosed |
| US-9790483-B2 | Reagents and methods for esterification | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2017-10-17 | — | — | US | disclosed |
| US-20160297752-A1 | REAGENTS AND METHODS FOR ESTERIFICATION | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11180748-B2 | Reagents and methods for esterification | VIP, BCR, TMPO | NPC1 783/4885RAB9A 1621/4885HPGD 3262/4885 |
| US-10428323-B2 | Reagents and methods for esterification | VIP, BCR, TMPO | NPC1 724/4885RAB9A 1620/4885HPGD 3185/4885 |
| US-20180037881-A1 | Reagents and Methods for Esterification | VIP, BCR, TMPO | NPC1 724/4885RAB9A 1620/4885HPGD 3185/4885 |
| US-20160297752-A1 | REAGENTS AND METHODS FOR ESTERIFICATION | VIP, BCR, TMPO | NPC1 724/4885RAB9A 1620/4885HPGD 3185/4885 |
| US-20200032238-A1 | Reagents and Methods for Esterification | VIP, BCR, TMPO | NPC1 783/4885RAB9A 1621/4885HPGD 3262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.