Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HB | P07237 | 1/20 | 0.82 |
| ▸ | MDM2 | Q00987 | 6/20 | 0.76 |
| ▸ | MAPT | P10636 | 2/20 | 0.75 |
| ▸ | TP53 | P04637 | 1/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.75 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20965575 | 1.00 | P4HB (0.82) | P4HBMDM2MAPTTP53SMN1; SMN2 | |
| SCHEMBL18131755 | 1.00 | P4HB (0.82) | P4HBMDM2MAPTTP53SMN1; SMN2 | |
| SCHEMBL18131752 | 0.88 | MAPT (0.81) | P4HBMDM2MAPTTP53SMN1; SMN2 | |
| SCHEMBL14961226 | 0.88 | MAPT (0.81) | P4HBMDM2MAPTTP53SMN1; SMN2 | |
| SCHEMBL18131664 | 0.88 | MAPT (0.81) | P4HBMDM2MAPTTP53SMN1; SMN2 | |
| SCHEMBL1701293 | 0.88 | MAPT (0.81) | P4HBMDM2MAPTTP53SMN1; SMN2 | |
| SCHEMBL12297841 | 0.87 | MAPT (0.68) | P4HBMDM2MAPTTP53SMN1; SMN2 | |
| SCHEMBL18131633 | 0.87 | MDM2 (0.86) | P4HBMDM2MAPTTP53SMN1; SMN2 | |
| SCHEMBL21519576 | 0.87 | MDM2 (0.86) | P4HBMDM2MAPTTP53SMN1; SMN2 | |
| SCHEMBL18131645 | 0.87 | MDM2 (0.86) | P4HBMDM2MAPTTP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190330188-A1 | ENANTIOMERS OF 8-HYDROXYQUINOLINE DERIVATIVES AND THE SYNTHESIS THEREOF | AVIDIN CO. LTD (HU) | 2019-10-31 | — | — | US | disclosed |
| US-10287265-B2 | Enantiomers of 8-hydroxyquinoline derivatives and the synthesis thereof | AVIDIN CO. LTD. (HU) | 2019-05-14 | — | — | US | disclosed |
| EP-3268357-A1 | ENANTIOMERS OF 8-HYDROXY QUINOLINE DERIVATIVES AND THE SYNTHESIS THEREOF | Avidin Co. Ltd. (HU) | 2018-01-17 | — | — | EP | disclosed |
| US-20170197936-A1 | ENANTIOMERS OF 8-HYDROXYQUINOLINE DERIVATIVES AND THE SYNTHESIS THEREOF | SYNAGING SAS (FR) | 2017-07-13 | — | — | US | disclosed |
| WO-2016162706-A1 | ENANTIOMERS OF 8-HYDROXY QUINOLINE DERIVATIVES AND THE SYNTHESIS THEREOF | AVIDIN CO. LTD. (HU) | 2016-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10287265-B2 | Enantiomers of 8-hydroxyquinoline derivatives and the synthesis thereof | TPH1, HTR5A, TPH2 | P4HB 2223/4885MDM2 3814/4885MAPT 3429/4885 |
| US-20190330188-A1 | ENANTIOMERS OF 8-HYDROXYQUINOLINE DERIVATIVES AND THE SYNTHESIS THEREOF | TPH1, TPH2, HTR5A | P4HB 1943/4885MDM2 2226/4885MAPT 2690/4885 |
| US-20170197936-A1 | ENANTIOMERS OF 8-HYDROXYQUINOLINE DERIVATIVES AND THE SYNTHESIS THEREOF | TPH1, HTR5A, TPH2 | P4HB 2223/4885MDM2 3814/4885MAPT 3429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.