Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.81 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.81 |
| ▸ | TP53 | P04637 | 3/20 | 0.81 |
| ▸ | MDM2 | Q00987 | 7/20 | 0.77 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | TTR | P02766 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.63 |
| ▸ | P4HB | P07237 | 3/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18131752 | 1.00 | MAPT (0.81) | MAPTSMN1; SMN2TP53MDM2GAA | |
| SCHEMBL18131664 | 1.00 | MAPT (0.81) | MAPTSMN1; SMN2TP53MDM2GAA | |
| SCHEMBL14961226 | 0.92 | MAPT (0.81) | MAPTSMN1; SMN2TP53MDM2GAA | |
| SCHEMBL18197735 | 0.90 | TP53 (0.79) | MAPTSMN1; SMN2TP53MDM2GAA | |
| SCHEMBL15783135 | 0.90 | MAPT (1.00) | MAPTSMN1; SMN2TP53MDM2LMNA | |
| SCHEMBL18131755 | 0.88 | P4HB (0.82) | MAPTSMN1; SMN2TP53MDM2LMNA | |
| SCHEMBL20965575 | 0.88 | P4HB (0.82) | MAPTSMN1; SMN2TP53MDM2LMNA | |
| SCHEMBL18131663 | 0.88 | P4HB (0.82) | MAPTSMN1; SMN2TP53MDM2LMNA | |
| SCHEMBL15783076 | 0.87 | GRK6 (0.77) | MAPTSMN1; SMN2TP53MDM2GAA | |
| SCHEMBL16508617 | 0.87 | MAPT (0.74) | MAPTSMN1; SMN2TP53MDM2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130131096-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | UBICHEM KUTATO KORLATOLT FELELOSSEGU TARSASAG (HU) | 2013-05-23 | — | — | US | claimed |
| EP-2566849-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | "Avidin" Kutató, Fejleszt És Kereskedelmi Korlatolt Felelossegu Tarsasag (HU) | 2013-03-13 | — | — | EP | claimed |
| WO-2011148208-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | "AVIDIN" KUTATÓ, FEJLESZTŐ ÉS KERESKEDELMI KORLÁTOLT FELELŐSSÉGŰ TÁRSASÁG (HU) | 2011-12-01 | — | — | WO | claimed |
| US-20190330188-A1 | ENANTIOMERS OF 8-HYDROXYQUINOLINE DERIVATIVES AND THE SYNTHESIS THEREOF | AVIDIN CO. LTD (HU) | 2019-10-31 | — | — | US | disclosed |
| EP-2566849-B1 | 8-HYDROXY-QUINOLINE DERIVATIVES | AVIDIN KUTATO FEJLESZTOE ES KERESKEDELMI KORLATOLT FELELOESSEGUE TARSASAG (HU) | 2019-09-18 | — | — | EP | disclosed |
| EP-2566849-B1 | 8-HYDROXY-QUINOLINE DERIVATIVES | AVIDIN KUTATO FEJLESZTOE ES KERESKEDELMI KORLATOLT FELELOESSEGUE TARSASAG (HU) | 2019-09-18 | — | — | EP | disclosed |
| US-10287265-B2 | Enantiomers of 8-hydroxyquinoline derivatives and the synthesis thereof | AVIDIN CO. LTD. (HU) | 2019-05-14 | — | — | US | disclosed |
| US-8871937-B2 | 8-hydroxy-quinoline derivatives | “AVIDIN” Kutato, Fejleszto es Kereskedelmi Korlatolt Felelossegu Tarsasag (HU) | 2014-10-28 | — | — | US | disclosed |
| US-8871937-B2 | 8-hydroxy-quinoline derivatives | “AVIDIN” Kutato, Fejleszto es Kereskedelmi Korlatolt Felelossegu Tarsasag (HU) | 2014-10-28 | — | — | US | disclosed |
| US-8871937-B2 | 8-hydroxy-quinoline derivatives | “AVIDIN” Kutato, Fejleszto es Kereskedelmi Korlatolt Felelossegu Tarsasag (HU) | 2014-10-28 | — | — | US | disclosed |
| US-20130131096-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | UBICHEM KUTATO KORLATOLT FELELOSSEGU TARSASAG (HU) | 2013-05-23 | — | — | US | disclosed |
| US-20130131096-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | UBICHEM KUTATO KORLATOLT FELELOSSEGU TARSASAG (HU) | 2013-05-23 | — | — | US | disclosed |
| US-20130131096-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | UBICHEM KUTATO KORLATOLT FELELOSSEGU TARSASAG (HU) | 2013-05-23 | — | — | US | disclosed |
| EP-2566849-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | "Avidin" Kutató, Fejleszt És Kereskedelmi Korlatolt Felelossegu Tarsasag (HU) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011148208-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | "AVIDIN" KUTATÓ, FEJLESZTŐ ÉS KERESKEDELMI KORLÁTOLT FELELŐSSÉGŰ TÁRSASÁG (HU) | 2011-12-01 | — | — | WO | disclosed |
| WO-2011148208-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | "AVIDIN" KUTATÓ, FEJLESZTŐ ÉS KERESKEDELMI KORLÁTOLT FELELŐSSÉGŰ TÁRSASÁG (HU) | 2011-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10287265-B2 | Enantiomers of 8-hydroxyquinoline derivatives and the synthesis thereof | TPH1, HTR5A, TPH2 | MAPT 3429/4885SMN1; SMN2 1255/4885TP53 4452/4885 |
| US-20190330188-A1 | ENANTIOMERS OF 8-HYDROXYQUINOLINE DERIVATIVES AND THE SYNTHESIS THEREOF | TPH1, TPH2, HTR5A | MAPT 2690/4885SMN1; SMN2 677/4885TP53 3980/4885 |
| US-20130131096-A1 | 8-HYDROXY-QUINOLINE DERIVATIVES | CYP2C8, NQO1, KEAP1 | MAPT 2319/4885SMN1; SMN2 1845/4885TP53 4173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.