Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 13/20 | 0.66 |
| ▸ | BRD2 | P25440 | 12/20 | 0.66 |
| ▸ | BRD3 | Q15059 | 12/20 | 0.66 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.54 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.54 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.54 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.54 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.54 |
| ▸ | GABRP | O00591 | 1/20 | 0.54 |
| ▸ | GABRD | O14764 | 1/20 | 0.54 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.54 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.54 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.54 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.54 |
| ▸ | GABRE | P78334 | 1/20 | 0.54 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.54 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.54 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.54 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1871652 | 0.80 | BRD4 (1.00) | BRD4BRD2BRD3GABRA1GABRA5 | |
| Formic Acid SCHEMBL9470611 | 0.74 | BRD4 (0.86) | BRD4BRD2BRD3GABRA1GABRA5 | |
| SCHEMBL1810706 | 0.72 | BRD4 (0.54) | BRD4BRD2BRD3GABRA1GABRA5 | |
| SCHEMBL9565446 | 0.72 | BRD4 (0.54) | BRD4BRD2BRD3GABRA1GABRA5 | |
| SCHEMBL11961522 | 0.72 | BRD4 (0.85) | BRD4BRD2BRD3GABRA1GABRA5 | |
| SCHEMBL11828757 | 0.72 | OPRK1 (0.58) | BRD4BRD2BRD3GABRA1GABRA5 | |
| SCHEMBL1835654 | 0.70 | GABRA1 (1.00) | BRD4BRD2BRD3GABRA1GABRA5 | |
| SCHEMBL2923672 | 0.70 | GABRA1 (1.00) | BRD4BRD2BRD3GABRA1GABRA5 | |
| SCHEMBL2929181 | 0.70 | GABRA1 (1.00) | BRD4BRD2BRD3GABRA1GABRA5 | |
| SCHEMBL8879373 | 0.70 | BRD4 (0.81) | BRD4BRD2BRD3CCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912653-B1 | HETEROCYCLIC BENZODIAZEPINE CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2014-01-01 | — | — | EP | disclosed |
| US-7947678-B2 | Heterocyclic benzodiazepine CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2011-05-24 | — | — | US | disclosed |
| US-20090105228-A1 | Heterocyclic benzodiazepine cgrp receptor antagonists | MERCK SHARP & DOHME LLC | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105228-A1 | Heterocyclic benzodiazepine cgrp receptor antagonists | BDKRB2, BDKRB1, CCKBR | BRD4 751/4885BRD2 623/4885BRD3 624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.