Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 3/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.37 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.37 |
| ▸ | PNMT | P11086 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27889659 | 0.81 | HTT (0.47) | FOLH1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL6958711 | 0.78 | CYP2C9 (0.43) | KIF11SLC6A9PARP1MEN1KMT2A | |
| SCHEMBL4421523 | 0.77 | CYP2C9 (0.42) | KIF11SLC6A9PARP1MEN1KMT2A | |
| SCHEMBL4370914 | 0.72 | MEN1 (0.44) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL6983317 | 0.69 | MEN1 (0.63) | KIF11PARP1MEN1KMT2AAOC3 | |
| SCHEMBL6976406 | 0.69 | MEN1 (0.63) | KIF11PARP1MEN1KMT2AAOC3 | |
| SCHEMBL6985765 | 0.69 | MEN1 (0.63) | KIF11PARP1MEN1KMT2AAOC3 | |
| SCHEMBL934324 | 0.69 | EPHX1 (0.51) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL1197606 | 0.68 | APEX1 (0.64) | MEN1KMT2ACYP2C19HSD17B10ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7589164 | 0.68 | MEN1 (0.61) | KIF11PARP1MEN1KMT2AAOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110124705-A1 | PRODRUGS OF ALPHA-2-DELTA LIGANDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | XENOPORT, INC. (US) | 2011-05-26 | — | — | US | claimed |
| US-20090286875-A1 | ISOCYSTENE DERIVATIVES FOR THE TREATMENT OF PAIN | PFIZER, INC. (US) | 2009-11-19 | — | — | US | claimed |
| EP-1954260-A2 | ISOCYSTENE DERIVATIVES FOR THE TREATMENT OF PAIN | Pfizer Limited (GB) | 2008-08-13 | — | — | EP | claimed |
| WO-2007057756-A2 | ISOCYSTENE DERIVATIVES FOR THE TREATMENT OF PAIN | PFIZER LIMITED (GB) | 2007-05-24 | — | — | WO | claimed |
| US-20110130454-A1 | PRODRUGS OF GAMMA-AMINO ACID, ALPHA-2-DELTA LIGANDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | XENOPORT, INC. (US) | 2011-06-02 | — | — | US | disclosed |
| US-20110124705-A1 | PRODRUGS OF ALPHA-2-DELTA LIGANDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | XENOPORT, INC. (US) | 2011-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130454-A1 | PRODRUGS OF GAMMA-AMINO ACID, ALPHA-2-DELTA LIGANDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | CHRND, CHRNE, OPRD1 | FOLH1 82/4885KIF11 4874/4885SLC6A9 2434/4885 |
| US-20090286875-A1 | ISOCYSTENE DERIVATIVES FOR THE TREATMENT OF PAIN | IDH3A, ACHE, SDHA | FOLH1 2561/4885KIF11 2441/4885SLC6A9 2914/4885 |
| US-20110124705-A1 | PRODRUGS OF ALPHA-2-DELTA LIGANDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | CHRND, CHRNE, CHRNG | FOLH1 305/4885KIF11 4839/4885SLC6A9 4003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.