Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TERT | O14746 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TYMP | P19971 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4421523 | 0.84 | CYP2C9 (0.42) | CYP2C9CYP2C19HSD17B10TERTKIF11 | |
| SCHEMBL1814201 | 0.78 | FOLH1 (0.45) | CYP2C9CYP2C19HSD17B10KIF11PARP1 | |
| SCHEMBL6960077 | 0.78 | KIF11 (0.40) | HSD17B10TERTKIF11PARP1MEN1 | |
| SCHEMBL6965136 | 0.78 | LMNA (0.46) | CYP2C9CYP2C19HSD17B10MAPTLMNA | |
| SCHEMBL7369925 | 0.77 | ALOX12 (0.44) | MAPTHTTNPC1TRPM5ALDH1A1 | |
| SCHEMBL934324 | 0.75 | EPHX1 (0.51) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL6956928 | 0.74 | CES2 (0.47) | MEN1KMT2AMAPTHTTRAB9A | |
| SCHEMBL12125560 | 0.72 | GRM5 (0.49) | CYP2C9CYP2C19MEN1KMT2ALMNA | |
| SCHEMBL6959322 | 0.72 | EPHX1 (0.57) | KIF11MEN1KMT2AMAPTNPC1 | |
| SCHEMBL4540229 | 0.72 | LMNA (0.54) | MEN1KMT2AMAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729465-B1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE DAVIS & CO (US) | 2003-01-22 | — | — | EP | disclosed |
| US-6005103-A | TREATMENT OF BACTERIAL AND VIRAL INFECTIONS AND DISEASES, INCLUDING AIDS | WARNER-LAMBERT COMPANY (US) | 1999-12-21 | — | — | US | disclosed |
| US-5808062-A | AIDS THERAPY | WARNER-LAMBERT COMPANY (US) | 1998-09-15 | — | — | US | disclosed |