Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 11/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.56 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.56 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.56 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.56 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RORA | P35398 | 1/20 | 0.52 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.50 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.50 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18156906 | 0.90 | ALDH1A1 (0.63) | RORCALDH1A1ABCC9ABCC8KCNJ11 | |
| SCHEMBL17114558 | 0.87 | RORC (0.80) | RORCRORA | |
| SCHEMBL18151624 | 0.87 | RORC (0.60) | RORCALDH1A1ABCC9ABCC8KCNJ11 | |
| SCHEMBL17114492 | 0.86 | RORC (1.00) | RORCRORA | |
| SCHEMBL18151717 | 0.85 | RORC (0.77) | RORCRORA | |
| SCHEMBL18151427 | 0.84 | RORC (0.75) | RORCRORA | |
| SCHEMBL18151719 | 0.83 | RORC (0.77) | RORCALDH1A1MAPTRORALMNA | |
| SCHEMBL16799908 | 0.83 | RORC (0.85) | RORCRORA | |
| SCHEMBL16799969 | 0.82 | RORC (0.79) | RORCRORA | |
| SCHEMBL18151212 | 0.82 | RORC (0.72) | RORCALDH1A1RORALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3077372-B1 | ROR GAMMA (RORY) MODULATORS | LEAD PHARMA HOLDING BV (NL) | 2019-02-06 | — | — | EP | claimed |
| US-9738600-B2 | ROR gamma (RORγ) modulators | LEAD PHARMA CEL MODELS IP B.V. (NL) | 2017-08-22 | — | — | US | claimed |
| US-20160304448-A1 | ROR GAMMA (RORy) MODULATORS | LEAD PHARMA CEL MODELS IP B.V. (NL) | 2016-10-20 | — | — | US | claimed |
| EP-3077372-B1 | ROR GAMMA (RORY) MODULATORS | LEAD PHARMA HOLDING BV (NL) | 2019-02-06 | — | — | EP | disclosed |
| US-9738600-B2 | ROR gamma (RORγ) modulators | LEAD PHARMA CEL MODELS IP B.V. (NL) | 2017-08-22 | — | — | US | disclosed |
| US-9738600-B2 | ROR gamma (RORγ) modulators | LEAD PHARMA CEL MODELS IP B.V. (NL) | 2017-08-22 | — | — | US | disclosed |
| US-20160304448-A1 | ROR GAMMA (RORy) MODULATORS | LEAD PHARMA CEL MODELS IP B.V. (NL) | 2016-10-20 | — | — | US | disclosed |
| US-20160304448-A1 | ROR GAMMA (RORy) MODULATORS | LEAD PHARMA CEL MODELS IP B.V. (NL) | 2016-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160304448-A1 | ROR GAMMA (RORy) MODULATORS | RORC, RORA, RORB | RORC 1/4885ALDH1A1 1054/4885ABCC9 1946/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.