Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | CFD | P00746 | 2/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.31 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.31 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.31 |
| ▸ | MPO | P05164 | 1/20 | 0.30 |
| ▸ | C1R | P00736 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1060289 | 0.77 | MAOA (0.34) | CYP3A4TSHRMAPK1 | |
| SCHEMBL2274975 | 0.69 | MAOA (0.39) | ADORA2AADORA1NPC1ALDH1A1CYP3A4 | |
| SCHEMBL1062624 | 0.69 | DYRK1A (0.44) | ADORA2AADORA1NPC1ALDH1A1TSHR | |
| SCHEMBL1062470 | 0.69 | TDO2 (0.46) | ADORA2ANPC1ALDH1A1CYP3A4TSHR | |
| SCHEMBL1062365 | 0.68 | ADORA2A (0.38) | ADORA2AADORA1CFDCYP3A4 | |
| SCHEMBL1063264 | 0.68 | ASIC3 (0.46) | ADORA2AADORA1CFDNPC1ALDH1A1 | |
| SCHEMBL9825550 | 0.67 | SLC22A12 (0.40) | ADORA2AADORA1CFDCASP3SENP8 | |
| SCHEMBL25082856 | 0.66 | CYP3A4 (0.41) | ALDH1A1TP53CYP3A4TSHRMAPK1 | |
| SCHEMBL21438495 | 0.66 | MAPT (0.41) | ADORA2AADORA1ALDH1A1CYP3A4TSHR | |
| SCHEMBL7484618 | 0.66 | PDE10A (0.39) | NPC1ALDH1A1CYP3A4TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283077-A2 | BROMODOMAIN INHIBITOR | Celgene Quanticel Research, Inc. (US) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016168682-A2 | BROMODOMAIN INHIBITOR | CELGENE QUANTICEL RESEARCH, INC. (US) | 2016-10-20 | — | — | WO | disclosed |