Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KLK7 | P49862 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2749595 | 0.80 | ACHE (0.38) | ACHEHDAC8 | |
| SCHEMBL422388 | 0.77 | ACHE (0.42) | ACHEHDAC8 | |
| SCHEMBL422097 | 0.73 | HDAC8 (0.33) | HDAC8 | |
| SCHEMBL5290160 | 0.73 | HDAC8 (0.33) | HDAC8 | |
| SCHEMBL5301083 | 0.70 | CA1 (0.30) | — | |
| SCHEMBL20953975 | 0.69 | ACHE (0.33) | ACHE | |
| Iodide SCHEMBL597041 | 0.69 | — | — | |
| SCHEMBL5283594 | 0.68 | CA1 (0.36) | — | |
| SCHEMBL5287375 | 0.66 | SLC22A2 (0.38) | ACHEKDM4EALDH1A1GAAHPGD | |
| SCHEMBL21049611 | 0.66 | USP2 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12606666-B2 | Imidazoles and imidazolium cations with exceptional alkaline stability | CORNELL UNIVERSITY (US) | 2026-04-21 | — | — | US | disclosed |
| EP-4108691-A1 | IMIDAZOLIUM CATIONS WITH EXCEPTIONAL ALKALINE STABILITY | Cornell University (US) | 2022-12-28 | — | — | EP | disclosed |
| EP-3283535-B1 | POLYMERS COMPRISING IMIDAZOLIUM CATIONS WITH EXCEPTIONAL ALKALINE STABILITY | UNIV CORNELL (US) | 2022-08-10 | — | — | EP | disclosed |
| US-20220127413-A1 | IMIDAZOLES AND IMIDAZOLIUM CATIONS WITH EXCEPTIONAL ALKALINE STABILITY | CORNELL UNIVERSITY (US) | 2022-04-28 | — | — | US | disclosed |
| US-11242432-B2 | Imidazoles and imidazolium cations with exceptional alkaline stability | CORNELL UNIVERSITY (US) | 2022-02-08 | — | — | US | disclosed |
| CN-108026213-B | Imidazole and imidazolium cations with special base stability | 康奈尔大学 | 2021-11-02 | — | — | CN | disclosed |
| US-20190047963-A1 | IMIDAZOLES AND IMIDAZOLIUM CATIONS WITH EXCEPTIONAL ALKALINE STABILITY | CORNELL UNIVERSITY (US) | 2019-02-14 | — | — | US | disclosed |
| CN-108026213-A | Imidazoles and glyoxaline cation with special alkaline stability | 康奈尔大学 | 2018-05-11 | — | — | CN | disclosed |
| EP-3283535-A2 | IMIDAZOLES AND IMIDAZOLIUM CATIONS WITH EXCEPTIONAL ALKALINE STABILITY | Cornell University (US) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016168468-A2 | IMIDAZOLES AND IMIDAZOLIUM CATIONS WITH EXCEPTIONAL ALKALINE STABILITY | CORNELL UNIVERSITY (US) | 2016-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220127413-A1 | IMIDAZOLES AND IMIDAZOLIUM CATIONS WITH EXCEPTIONAL ALKALINE STABILITY | ALPI, ITPA, ITPR2 | ACHE 535/4885KDM4E 1492/4885ALDH1A1 1091/4885 |
| US-20190047963-A1 | IMIDAZOLES AND IMIDAZOLIUM CATIONS WITH EXCEPTIONAL ALKALINE STABILITY | ALPI, ITPA, ITPR2 | ACHE 535/4885KDM4E 1492/4885ALDH1A1 1091/4885 |
| US-11242432-B2 | Imidazoles and imidazolium cations with exceptional alkaline stability | ALPI, ITPA, ITPR2 | ACHE 535/4885KDM4E 1492/4885ALDH1A1 1091/4885 |
| US-12606666-B2 | Imidazoles and imidazolium cations with exceptional alkaline stability | SCO2, RCC1, SMC2 | ACHE 3107/4885KDM4E 1633/4885ALDH1A1 476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.