Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18152668 | 0.73 | HTT (0.31) | HTT | |
| SCHEMBL18152662 | 0.71 | SCN9A (0.33) | HSD17B10MAPTHPGD | |
| SCHEMBL18152633 | 0.67 | USP30 (0.34) | KDM4EHPGD | |
| SCHEMBL18152659 | 0.65 | ADRB2 (0.33) | HTT | |
| SCHEMBL27156172 | 0.62 | ADRB2 (0.48) | POLBGSK3BHTTKDM4EHSD17B10 | |
| SCHEMBL4381077 | 0.62 | HTT (0.47) | HTTHPGD | |
| SCHEMBL22516867 | 0.61 | BRD4 (0.39) | POLBHTTKDM4EHSD17B10HPGD | |
| SCHEMBL18152714 | 0.59 | ALDH1A1 (0.40) | RIPK1POLBMAPTHPGDCYP1A2 | |
| SCHEMBL28295713 | 0.59 | HTT (0.45) | HTTKDM4EMAPTHPGDCYP3A4 | |
| SCHEMBL13544184 | 0.59 | SMN1; SMN2 (0.50) | RIPK1HTTMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283077-A2 | BROMODOMAIN INHIBITOR | Celgene Quanticel Research, Inc. (US) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016168682-A2 | BROMODOMAIN INHIBITOR | CELGENE QUANTICEL RESEARCH, INC. (US) | 2016-10-20 | — | — | WO | disclosed |