Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.32 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18152662 | 0.81 | SCN9A (0.33) | GRIN1GRIN2BALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL18152793 | 0.78 | MEN1 (0.32) | TRPV1 | |
| SCHEMBL18152659 | 0.68 | ADRB2 (0.33) | — | |
| SCHEMBL18152783 | 0.67 | RIPK1 (0.33) | KDM4EHPGD | |
| SCHEMBL11684204 | 0.60 | KDM4E (0.42) | TRPV1ALDH1A1LMNASMN1; SMN2KDM4E | |
| SCHEMBL18152668 | 0.59 | HTT (0.31) | — | |
| SCHEMBL18152624 | 0.59 | HTT (0.33) | — | |
| SCHEMBL7002106 | 0.59 | RIPK1 (0.55) | CACNA1HCACNA1GALDH1A1KDM4EHPGD | |
| SCHEMBL9204907 | 0.57 | CACNA1H (0.37) | CACNA1HCACNA1GTRPV1ALDH1A1LMNA | |
| SCHEMBL28390672 | 0.57 | MAPT (0.59) | CACNA1HALDH1A1LMNASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283077-A2 | BROMODOMAIN INHIBITOR | Celgene Quanticel Research, Inc. (US) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016168682-A2 | BROMODOMAIN INHIBITOR | CELGENE QUANTICEL RESEARCH, INC. (US) | 2016-10-20 | — | — | WO | disclosed |