SCHEMBL18154017

SCHEMBL18154017

COc1ccc(C=Cc2cc(F)cc(OC)c2)cc1

nearest known ligand 0.86

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NQO2 P16083 4/20 0.75
ESR1 P03372 3/20 0.75
CYP1A1 P04798 3/20 0.75
PTGS2 P35354 3/20 0.75
CYP1B1 Q16678 3/20 0.75
AHR P35869 3/20 0.75
ABL1 P00519 2/20 0.75
TTR P02766 2/20 0.75
ABCB1 P08183 2/20 0.75
ALOX5 P09917 2/20 0.75
BCR P11274 2/20 0.75
CYP19A1 P11511 2/20 0.75
TUBB1 Q9H4B7 2/20 0.75
CYP1A2 P05177 1/20 0.75
TUBB4A P04350 1/20 0.75
TUBB P07437 1/20 0.75
TUBA3C P0DPH7 1/20 0.75
TUBA1B P68363 1/20 0.75
TUBA4A P68366 1/20 0.75
TUBB4B P68371 1/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6470139 0.92 NFE2L2 (0.74) NQO2ESR1CYP1A1PTGS2CYP1B1
SCHEMBL6470143 0.92 NFE2L2 (0.74) NQO2ESR1CYP1A1PTGS2CYP1B1
SCHEMBL6461623 0.92 NFE2L2 (0.74) NQO2ESR1CYP1A1PTGS2CYP1B1
SCHEMBL28901331 0.87 KDM4E (0.67) NQO2ESR1CYP1A1PTGS2CYP1B1
SCHEMBL3758141 0.86 CYP1A1 (0.91) NQO2ESR1CYP1A1PTGS2CYP1B1
Trismethoxyresveratrol SCHEMBL918740 0.86 CYP1A1 (1.00) NQO2ESR1CYP1A1PTGS2CYP1B1
8Z-3,4',5-Trimethoxystilbene SCHEMBL1006207 0.86 CYP1A1 (1.00) NQO2ESR1CYP1A1PTGS2CYP1B1
Trismethoxyresveratrol SCHEMBL918739 0.86 CYP1A1 (1.00) NQO2ESR1CYP1A1PTGS2CYP1B1
SCHEMBL13443549 0.86 CYP1A1 (0.91) NQO2ESR1CYP1A1PTGS2CYP1B1
SCHEMBL6463507 0.85 NQO2 (1.00) NQO2ESR1CYP1A1PTGS2CYP1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3283459-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO Dow Agrosciences LLC (US) 2018-02-21 EP disclosed
WO-2016168059-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO DOW AGROSCIENCES LLC (US) 2016-10-20 WO disclosed