Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 5/20 | 0.91 |
| ▸ | CYP1B1 | Q16678 | 5/20 | 0.91 |
| ▸ | ESR1 | P03372 | 4/20 | 0.91 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.91 |
| ▸ | NQO2 | P16083 | 4/20 | 0.91 |
| ▸ | AHR | P35869 | 3/20 | 0.91 |
| ▸ | TTR | P02766 | 3/20 | 0.91 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.91 |
| ▸ | ABL1 | P00519 | 2/20 | 0.91 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.91 |
| ▸ | BCR | P11274 | 2/20 | 0.91 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.91 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.91 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.91 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.91 |
| ▸ | TUBB | P07437 | 1/20 | 0.91 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.91 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.91 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.91 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.91 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3758141 | 1.00 | CYP1A1 (0.91) | CYP1A1CYP1B1ESR1PTGS2NQO2 | |
| Trismethoxyresveratrol SCHEMBL918739 | 0.95 | CYP1A1 (1.00) | CYP1A1CYP1B1ESR1PTGS2NQO2 | |
| 8Z-3,4',5-Trimethoxystilbene SCHEMBL1006207 | 0.95 | CYP1A1 (1.00) | CYP1A1CYP1B1ESR1PTGS2NQO2 | |
| Trismethoxyresveratrol SCHEMBL918740 | 0.95 | CYP1A1 (1.00) | CYP1A1CYP1B1ESR1PTGS2NQO2 | |
| SCHEMBL9177232 | 0.95 | TUBB1 (0.83) | CYP1A1CYP1B1ESR1PTGS2NQO2 | |
| SCHEMBL13409620 | 0.92 | RELA (0.81) | CYP1A1CYP1B1ESR1PTGS2NQO2 | |
| SCHEMBL631998 | 0.88 | RELA (0.81) | CYP1A1CYP1B1ESR1PTGS2NQO2 | |
| SCHEMBL13790336 | 0.88 | RELA (0.81) | CYP1A1CYP1B1ESR1PTGS2NQO2 | |
| SCHEMBL4881152 | 0.88 | RELA (0.81) | CYP1A1CYP1B1ESR1PTGS2NQO2 | |
| SCHEMBL699457 | 0.88 | RELA (0.81) | CYP1A1CYP1B1ESR1PTGS2NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170224637-A1 | INTRANSAL DELIVERY OF CURCUMIN | DePuy Synthes Products, Inc. (US) | 2017-08-10 | — | — | US | disclosed |
| US-20140163116-A1 | METHOD OF TREATING CANCER USING A CURCUMIN DERIVATIVE | DePuy Synthes Products, LLC (US) | 2014-06-12 | — | — | US | disclosed |
| US-20130150628-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A CURCUMIN DERIVATIVE | DIMAURO THOMAS M (US) | 2013-06-13 | — | — | US | disclosed |
| US-20100087527-A1 | Curcumin Derivatives | CODMAN & SHURTLEFF, INC. (US) | 2010-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150628-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A CURCUMIN DERIVATIVE | CPT1A, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, ABCB1 | CYP1A1 219/4885CYP1B1 163/4885ESR1 4692/4885 |
| US-20140163116-A1 | METHOD OF TREATING CANCER USING A CURCUMIN DERIVATIVE | HDAC5, HDAC6, CPT1A | CYP1A1 516/4885CYP1B1 254/4885ESR1 4561/4885 |
| US-20170224637-A1 | INTRANSAL DELIVERY OF CURCUMIN | FABP7, FABP2, NDUFB5 | CYP1A1 2788/4885CYP1B1 2621/4885ESR1 3380/4885 |
| US-20100087527-A1 | Curcumin Derivatives | CPT1A, S100A10, PKD1 | CYP1A1 439/4885CYP1B1 306/4885ESR1 4675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.