Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.48 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | STAT1 | P42224 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20519924 | 0.88 | GAA (0.62) | DGAT1SOAT1ALDH1A1NFKB1GAA | |
| SCHEMBL27854362 | 0.85 | FFAR4 (0.46) | ALDH1A1NFKB1SMN1; SMN2HPGDNPC1 | |
| SCHEMBL21368940 | 0.81 | HTR7 (0.59) | ICMT | |
| SCHEMBL3574310 | 0.81 | CTSA (0.50) | CYP1A2CYP3A4CYP2C19ALDH1A1TDP1 | |
| SCHEMBL29602721 | 0.81 | LMNA (0.61) | CYP1A2CYP3A4CYP2C19ALDH1A1GAA | |
| SCHEMBL1033641 | 0.81 | LMNA (0.61) | CYP1A2CYP3A4CYP2C19ALDH1A1GAA | |
| SCHEMBL28174998 | 0.80 | HPGD (0.51) | ALDH1A1NFKB1GAATSHRTDP1 | |
| SCHEMBL2570486 | 0.80 | CSNK2A1 (0.57) | CYP1A2CYP3A4CYP2C19ALDH1A1TDP1 | |
| SCHEMBL27815745 | 0.80 | CYP1A1 (0.46) | CYP1A2CYP3A4CYP2C19ALDH1A1NFKB1 | |
| SCHEMBL7349532 | 0.79 | TPH1 (0.57) | TDP1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2320886-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITION FOR THE TREATMENT OF COLLAPSING GLOMERULOPATHY AND OTHER GLOMERULAR DISEASE | Genzyme Corporation (US) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010014554-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITION FOR THE TREATMENT OF COLLAPSING GLOMERULOPATHY AND OTHER GLOMERULAR DISEASE | GENZYME CORPORATION (US) | 2010-02-04 | — | — | WO | disclosed |