Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 3/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.45 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | IDH2 | P48735 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18156926 | 0.92 | PDK1 (0.44) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL18151205 | 0.92 | RORC (0.46) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL18156907 | 0.88 | RORC (0.47) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL18156917 | 0.84 | MAPT (0.47) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL18156923 | 0.83 | LMNA (0.43) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL18151612 | 0.83 | RORC (0.44) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL18151700 | 0.81 | RORC (0.51) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL18151519 | 0.80 | RORC (0.54) | LMNAALDH1A1IDH2CYP2D6RORC | |
| SCHEMBL18156949 | 0.79 | PDK1 (0.46) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL18156924 | 0.79 | LMNA (0.43) | PDK1PDK2PDK3PDK4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9738600-B2 | ROR gamma (RORγ) modulators | LEAD PHARMA CEL MODELS IP B.V. (NL) | 2017-08-22 | — | — | US | disclosed |
| US-20160304448-A1 | ROR GAMMA (RORy) MODULATORS | LEAD PHARMA CEL MODELS IP B.V. (NL) | 2016-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160304448-A1 | ROR GAMMA (RORy) MODULATORS | RORC, RORA, RORB | PDK1 3903/4885PDK2 4057/4885PDK3 3755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.