SCHEMBL18157770

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL18157776	0.79	ALK (0.42)	ALKCYP11B1CYP11B2KDM4EMEN1
	SCHEMBL18157765	0.77	ALK (0.50)	ALKKDM4EMEN1NPC1RAB9A
	SCHEMBL18157747	0.77	ALK (0.50)	ALKKDM4EMEN1NPC1RAB9A
	SCHEMBL20223300	0.77	CYP11B1 (0.58)	ALKCYP11B1CYP11B2AURKAKDM4E
	SCHEMBL18157768	0.75	KDM4E (0.42)	ALKCYP11B1CYP11B2PARP1KDM4E
	SCHEMBL18157755	0.75	NPC1 (0.50)	ALKKDM4EMEN1NPC1RAB9A
	SCHEMBL28555372	0.75	NPC1 (0.50)	ALKKDM4EMEN1NPC1RAB9A
	SCHEMBL18157762	0.74	ALK (0.50)	ALKCYP11B1CYP11B2AURKAKDM4E
	SCHEMBL18157727	0.73	CYP11B1 (0.53)	ALKCYP11B1CYP11B2AURKAKDM4E
	SCHEMBL20225455	0.72	CYP11B1 (0.51)	ALKCYP11B1CYP11B2AURKAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.