Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 3/20 | 0.68 |
| ▸ | IMPDH2 | P12268 | 6/20 | 0.68 |
| ▸ | IMPDH1 | P20839 | 2/20 | 0.68 |
| ▸ | TGM2 | P21980 | 1/20 | 0.66 |
| ▸ | P2RY1 | P47900 | 4/20 | 0.65 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.65 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.65 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.65 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.65 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.65 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.65 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.65 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.64 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.64 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.63 |
| ▸ | KRAS | P01116 | 2/20 | 0.62 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.62 |
| ▸ | NT5E | P21589 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18289612 | 1.00 | P2RX3 (0.68) | P2RX3IMPDH2IMPDH1TGM2P2RY1 | |
| SCHEMBL18269536 | 1.00 | P2RX3 (0.68) | P2RX3IMPDH2IMPDH1TGM2P2RY1 | |
| SCHEMBL15746475 | 0.93 | IMPDH2 (0.66) | P2RX3IMPDH2IMPDH1TGM2P2RY1 | |
| SCHEMBL16805270 | 0.93 | IMPDH2 (0.66) | P2RX3IMPDH2IMPDH1TGM2P2RY1 | |
| SCHEMBL15702882 | 0.93 | TGM2 (0.68) | P2RX3IMPDH2IMPDH1TGM2P2RY1 | |
| SCHEMBL15746465 | 0.92 | P2RX3 (0.58) | P2RX3IMPDH2IMPDH1TGM2P2RY1 | |
| SCHEMBL15746485 | 0.92 | IMPDH2 (0.65) | P2RX3IMPDH2IMPDH1TGM2P2RY1 | |
| SCHEMBL16805277 | 0.92 | IMPDH2 (0.65) | P2RX3IMPDH2IMPDH1TGM2P2RY1 | |
| SCHEMBL15746483 | 0.92 | P2RX3 (0.66) | P2RX3IMPDH2IMPDH1TGM2P2RY1 | |
| SCHEMBL16805280 | 0.92 | P2RX3 (0.66) | P2RX3IMPDH2IMPDH1TGM2P2RY1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170136132-A1 | ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF | MODERNA THERAPEUTICS, INC. (US) | 2017-05-18 | — | — | US | disclosed |
| US-20160354491-A1 | MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF | MODERNA THERAPEUTICS INC (US) | 2016-12-08 | — | — | US | disclosed |
| US-20160354492-A1 | MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF | MODERNA THERAPEUTICS INC (US) | 2016-12-08 | — | — | US | disclosed |
| US-20160348099-A1 | MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF | MODERNA THERAPEUTICS INC (US) | 2016-12-01 | — | — | US | disclosed |
| US-20160304552-A1 | MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF | MODERNA THERAPEUTICS, INC. | 2016-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160354492-A1 | MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF | NSUN2, ADAR, NSUN3 | P2RX3 3314/4885IMPDH2 451/4885IMPDH1 496/4885 |
| US-20160304552-A1 | MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF | NSUN2, ADAR, NSUN3 | P2RX3 3314/4885IMPDH2 451/4885IMPDH1 496/4885 |
| US-20160348099-A1 | MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF | NSUN2, ADAR, NSUN3 | P2RX3 3314/4885IMPDH2 451/4885IMPDH1 496/4885 |
| US-20170136132-A1 | ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF | NSUN2, RNGTT, NSUN3 | P2RX3 2081/4885IMPDH2 462/4885IMPDH1 586/4885 |
| US-20160354491-A1 | MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF | NSUN2, ADAR, NSUN3 | P2RX3 3314/4885IMPDH2 451/4885IMPDH1 496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.