Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | CDC14B | O60729 | 1/20 | 0.37 |
| ▸ | CDC14A | Q9UNH5 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | WEE1 | P30291 | 1/20 | 0.36 |
| ▸ | CTRC | Q99895 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16801040 | 0.98 | PARP1 (0.38) | PARP1CDC14BCDC14AABCG2CYP1A1 | |
| SCHEMBL18159553 | 0.96 | PLA2G2A (0.37) | PARP1CDC14BCDC14AABCG2CYP1A1 | |
| SCHEMBL16801265 | 0.92 | CRHBP (0.37) | PARP1CDC14BCDC14AABCG2CYP1A1 | |
| SCHEMBL16801269 | 0.91 | ALDH1A1 (0.44) | ABCG2CYP1A1CYP1A2FYNMAPK3 | |
| SCHEMBL16801073 | 0.91 | ALDH1A1 (0.40) | PARP1CDC14BCDC14AABCG2CYP1A1 | |
| SCHEMBL16801322 | 0.90 | WEE1 (0.35) | PARP1CDC14BCDC14AABCG2CYP1A1 | |
| SCHEMBL18159535 | 0.89 | PLA2G2A (0.37) | PARP1ABCG2CYP1A1CYP1A2FYN | |
| SCHEMBL21226907 | 0.89 | PLA2G2A (0.37) | PARP1CDC14BCDC14AABCG2CYP1A1 | |
| SCHEMBL18159559 | 0.87 | PLA2G2A (0.41) | PARP1ABCG2CYP1A1CYP1A2FYN | |
| SCHEMBL16801324 | 0.87 | PLA2G2A (0.38) | PARP1ABCG2CYP1A1CYP1A2FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11917913-B2 | Substituted oxepines | MERCK PATENT GMBH (DE) | 2024-02-27 | — | — | US | disclosed |
| US-10374170-B2 | Substituted oxepines | MERCK PATENT GMBH (DE) | 2019-08-06 | — | — | US | disclosed |
| US-20160308146-A1 | SUBSTITUTED OXEPINES | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | US | disclosed |
| US-20160308146-A1 | SUBSTITUTED OXEPINES | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11917913-B2 | Substituted oxepines | OXGR1, OXTR, OCIAD2 | PARP1 863/4885CDC14B 4190/4885CDC14A 3706/4885 |
| US-10374170-B2 | Substituted oxepines | OXGR1, OXTR, OCIAD2 | PARP1 863/4885CDC14B 4190/4885CDC14A 3706/4885 |
| US-20160308146-A1 | SUBSTITUTED OXEPINES | OXGR1, OXTR, OCIAD2 | PARP1 863/4885CDC14B 4190/4885CDC14A 3706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.