Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 4/20 | 0.37 |
| ▸ | PLA2G4A | P47712 | 4/20 | 0.37 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16801324 | 0.98 | PLA2G2A (0.38) | PLA2G2APLA2G4APLA2G10ABCG2CYP1A1 | |
| SCHEMBL21226907 | 0.97 | PLA2G2A (0.37) | PLA2G2APLA2G4APLA2G10ABCG2CYP1A1 | |
| SCHEMBL18159539 | 0.97 | PLA2G2A (0.40) | PLA2G2APLA2G4APLA2G10ABCG2CYP1A1 | |
| SCHEMBL18159559 | 0.91 | PLA2G2A (0.41) | PLA2G2APLA2G4APLA2G10ABCG2CYP1A1 | |
| SCHEMBL18159532 | 0.89 | PARP1 (0.37) | PLA2G2APLA2G4APLA2G10ABCG2CYP1A1 | |
| SCHEMBL16801040 | 0.87 | PARP1 (0.38) | PLA2G2APLA2G4APLA2G10ABCG2CYP1A1 | |
| SCHEMBL18159553 | 0.85 | PLA2G2A (0.37) | PLA2G2APLA2G4APLA2G10ABCG2CYP1A1 | |
| SCHEMBL25660921 | 0.83 | PLA2G2A (0.41) | PLA2G2APLA2G4APLA2G10ABCG2AHR | |
| SCHEMBL16801265 | 0.82 | CRHBP (0.37) | ABCG2CYP1A1CYP1A2FYNMAPK3 | |
| SCHEMBL16801073 | 0.81 | ALDH1A1 (0.40) | ABCG2CYP1A1CYP1A2FYNMAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11917913-B2 | Substituted oxepines | MERCK PATENT GMBH (DE) | 2024-02-27 | — | — | US | disclosed |
| US-10374170-B2 | Substituted oxepines | MERCK PATENT GMBH (DE) | 2019-08-06 | — | — | US | disclosed |
| US-20160308146-A1 | SUBSTITUTED OXEPINES | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | US | disclosed |
| US-20160308146-A1 | SUBSTITUTED OXEPINES | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11917913-B2 | Substituted oxepines | OXGR1, OXTR, OCIAD2 | PLA2G2A 3300/4885PLA2G4A 3696/4885PLA2G10 4376/4885 |
| US-10374170-B2 | Substituted oxepines | OXGR1, OXTR, OCIAD2 | PLA2G2A 3300/4885PLA2G4A 3696/4885PLA2G10 4376/4885 |
| US-20160308146-A1 | SUBSTITUTED OXEPINES | OXGR1, OXTR, OCIAD2 | PLA2G2A 3300/4885PLA2G4A 3696/4885PLA2G10 4376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.