Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARS1 | P56192 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18166408 | 0.92 | MARS1 (0.46) | MARS1DGAT2ROCK2ROCK1KMT2A | |
| SCHEMBL18166327 | 0.92 | ROCK1 (0.39) | SMN1; SMN2USP2TSHRDGAT2ROCK2 | |
| SCHEMBL18166354 | 0.91 | KMT2A (0.38) | WDR5DGAT2ROCK2ROCK1KMT2A | |
| SCHEMBL10243094 | 0.88 | WDR5 (0.40) | MARS1WDR5ROCK2ROCK1CYP3A4 | |
| SCHEMBL18166303 | 0.86 | ROCK1 (0.39) | SMN1; SMN2USP2TSHRDGAT2ROCK2 | |
| SCHEMBL18166345 | 0.86 | WDR5 (0.44) | MARS1WDR5TSHRKMT2AMEN1 | |
| SCHEMBL18036449 | 0.83 | DGAT2 (0.39) | TSHRDGAT2KMT2AMEN1LMNA | |
| SCHEMBL18166266 | 0.83 | KMT2A (0.43) | DGAT2ROCK2ROCK1KMT2ACYP3A4 | |
| SCHEMBL18166440 | 0.83 | MARS1 (0.40) | MARS1DGAT2KMT2AMEN1F2 | |
| SCHEMBL18166321 | 0.82 | KMT2A (0.44) | TSHRDGAT2ROCK2ROCK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038264-B1 | TETRAZOLE-SUBSTITUTED ARYLAMIDES | HOFFMANN LA ROCHE (CH) | 2016-10-26 | — | — | EP | claimed |