Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 2/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 4/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | SNCA | P37840 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20445884 | 0.80 | RPS6KB1 (0.49) | LPLLIPGNUDT1ARPGR | |
| SCHEMBL20445886 | 0.80 | RPS6KB1 (0.49) | LPLLIPGNUDT1ARPGR | |
| SCHEMBL18171882 | 0.79 | NUDT1 (0.40) | LPLLIPGNUDT1AR | |
| SCHEMBL18171877 | 0.79 | DGAT1 (0.43) | LPLLIPGEGFRDGAT1IRAK4 | |
| SCHEMBL18171880 | 0.77 | NUDT1 (0.42) | NUDT1ARPGRJAK2JAK3 | |
| SCHEMBL29339757 | 0.76 | AR (0.44) | LPLLIPGARPGRIDO1 | |
| SCHEMBL1818313 | 0.76 | LPL (0.38) | LPLLIPGIDO1TDO2EGFR | |
| SCHEMBL29414473 | 0.76 | LPL (0.38) | LPLLIPGIDO1TDO2EGFR | |
| SCHEMBL25606443 | 0.76 | EGFR (0.46) | LPLLIPGIDO1TDO2EGFR | |
| SCHEMBL31503579 | 0.74 | TLR9 (0.52) | LPLLIPGDGAT1PDGFRBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016170163-A1 | SUBSTITUTED QUINOXALINES AND BENZOTRIAZINE P70S6 KINASE INHIBITORS | SENTINEL ONCOLOGY LIMITED (GB) | 2016-10-27 | — | — | WO | disclosed |