Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | CASR | P41180 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27851794 | 0.78 | NUDT1 (0.47) | MEN1KMT2AHTT | |
| SCHEMBL780421 | 0.78 | NUDT1 (0.47) | MEN1KMT2AHTT | |
| SCHEMBL18171887 | 0.78 | NUDT1 (0.47) | MEN1KMT2AHTT | |
| SCHEMBL20445815 | 0.78 | LMNA (0.49) | LMNAHTR7HTR6CASRMEN1 | |
| SCHEMBL18171875 | 0.76 | HTT (0.46) | LMNASMN1; SMN2ALDH1A1HTTPDE10A | |
| SCHEMBL13226945 | 0.72 | PABPC1 (0.41) | MEN1KMT2AALDH1A1HTTCYP1A2 | |
| SCHEMBL24449038 | 0.70 | PDE10A (0.56) | MEN1KMT2ASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL14469653 | 0.70 | CASR (0.56) | LMNACASRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3730227 | 0.70 | CASR (0.50) | LMNAHTR7HTR6CASRMEN1 | |
| SCHEMBL6469053 | 0.70 | CASR (0.50) | LMNACASRMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016170163-A1 | SUBSTITUTED QUINOXALINES AND BENZOTRIAZINE P70S6 KINASE INHIBITORS | SENTINEL ONCOLOGY LIMITED (GB) | 2016-10-27 | — | — | WO | disclosed |