Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | PPARA | Q07869 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | HTT | P42858 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | PPARD | Q03181 | 3/20 | 0.49 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HTR1E | P28566 | 1/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18182095 | 0.83 | CSNK2A1 (0.53) | MAPTMEN1LMNAHTTKMT2A | |
| SCHEMBL16913143 | 0.82 | P2RX3 (0.48) | PPARAPPARDP2RX3LDHARORC | |
| SCHEMBL20128503 | 0.81 | CSNK2A1 (0.50) | MAPTMEN1LMNAHTTKMT2A | |
| SCHEMBL6005581 | 0.80 | PNMT (0.58) | PPARAPPARDSMN1; SMN2PPARG | |
| SCHEMBL5130053 | 0.80 | PNMT (0.58) | PPARAPPARDSMN1; SMN2PPARG | |
| SCHEMBL10274466 | 0.80 | CSNK2A1 (0.51) | MAPTMEN1LMNAHTTKMT2A | |
| SCHEMBL6003855 | 0.80 | PNMT (0.58) | PPARAPPARDSMN1; SMN2PPARG | |
| SCHEMBL16322462 | 0.78 | EPHX1 (0.47) | PPARAPPARDP2RX3LDHARORC | |
| SCHEMBL23964692 | 0.77 | CA2 (0.57) | MAPTPPARAMEN1LMNAKMT2A | |
| SCHEMBL21895817 | 0.77 | ACACB (0.53) | PPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10118920-B2 | Isoxazolyl substituted benzimidazoles | CELLCENTRIC LTD (GB) | 2018-11-06 | — | — | US | disclosed |
| US-20180127402-A1 | ISOXAZOLYL SUBSTITUTED BENZIMIDAZOLES | CELLCENTRIC LTD (GB) | 2018-05-10 | — | — | US | disclosed |
| CN-107750249-A | The benzimidazole of isoxazolyl substitution | 塞尔森瑞科有限责任公司 | 2018-03-02 | — | — | CN | disclosed |
| EP-3286183-A1 | ISOXAZOLYL SUBSTITUTED BENZIMIDAZOLES | Cellcentric Ltd (GB) | 2018-02-28 | — | — | EP | disclosed |
| WO-2016170324-A1 | ISOXAZOLYL SUBSTITUTED BENZIMIDAZOLES | CELLCENTRIC LTD (GB) | 2016-10-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180127402-A1 | ISOXAZOLYL SUBSTITUTED BENZIMIDAZOLES | EP300, HDAC3, HDAC1 | MAPT 4059/4885PPARA 1521/4885MEN1 3014/4885 |
| US-10118920-B2 | Isoxazolyl substituted benzimidazoles | EP300, HDAC3, HDAC1 | MAPT 4059/4885PPARA 1521/4885MEN1 3014/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.