Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | FPR1 | P21462 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL681885 | 0.91 | ALDH1A1 (0.53) | CYP2C9SMN1; SMN2ALDH1A1KDM4ERXFP1 | |
| SCHEMBL2234193 | 0.73 | ANXA2 (0.67) | CYP2C9SMN1; SMN2ALDH1A1KDM4ERXFP1 | |
| SCHEMBL18963025 | 0.73 | ALDH1A1 (0.61) | SMN1; SMN2ALDH1A1KDM4ERXFP1POLB | |
| SCHEMBL15563600 | 0.71 | ALDH1A1 (0.54) | CYP2C9ALDH1A1KDM4ERXFP1CYP2C19 | |
| SCHEMBL681123 | 0.70 | RXFP1 (0.61) | CYP2C9SMN1; SMN2ALDH1A1KDM4ERXFP1 | |
| SCHEMBL743730 | 0.70 | ALDH1A1 (0.58) | SMN1; SMN2ALDH1A1KDM4EPOLBHPGD | |
| SCHEMBL16904814 | 0.70 | TP53 (0.58) | CYP2C9SMN1; SMN2ALDH1A1KDM4ERXFP1 | |
| SCHEMBL682096 | 0.69 | SMN1; SMN2 (0.56) | CYP2C9SMN1; SMN2ALDH1A1RXFP1POLB | |
| SCHEMBL18219843 | 0.69 | TSHR (0.52) | SMN1; SMN2ALDH1A1KDM4ERXFP1POLB | |
| SCHEMBL12540672 | 0.69 | MEN1 (0.57) | SMN1; SMN2ALDH1A1KDM4ERXFP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016172545-A1 | CASTRATION-RESISTANT PROSTATE CANCER | NUTECH VENTURES (US) | 2016-10-27 | — | — | WO | disclosed |
| US-20160310528-A1 | Castration-Resistant Prostate Cancer | NUTECH VENTURES | 2016-10-27 | — | — | US | disclosed |
| US-20160310528-A1 | Castration-Resistant Prostate Cancer | NUTECH VENTURES | 2016-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160310528-A1 | Castration-Resistant Prostate Cancer | UGDH, G6PD, DPYD | CYP2C9 2040/4885SMN1; SMN2 4595/4885ALDH1A1 54/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.