Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 7/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.48 |
| ▸ | FPR1 | P21462 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1897714 | 0.79 | KDM4E (0.66) | KMT2AMEN1CYP3A4RXFP1ALDH1A1 | |
| SCHEMBL18963022 | 0.77 | ALDH1A1 (0.57) | RXFP1ALDH1A1NPSR1FPR1PPARG | |
| SCHEMBL19463211 | 0.66 | ALDH1A1 (0.82) | SMN1; SMN2KMT2AMEN1CYP3A4RXFP1 | |
| SCHEMBL11573931 | 0.66 | LMNA (0.57) | KMT2ATP53MAPK1LMNATSHR | |
| SCHEMBL30774074 | 0.64 | ALOX15 (0.63) | RXFP1ALDH1A1NPSR1PPARGNCOR2 | |
| SCHEMBL17919809 | 0.63 | THRA (0.59) | TP53MAPK1LMNATSHR | |
| SCHEMBL11987159 | 0.62 | LMNA (0.63) | SMN1; SMN2KMT2AMEN1POLBALDH1A1 | |
| SCHEMBL2234193 | 0.62 | ANXA2 (0.67) | SMN1; SMN2HTTKMT2AMEN1RXFP1 | |
| SCHEMBL3719137 | 0.62 | ALOX15 (0.58) | HTTKMT2AMEN1RXFP1POLB | |
| SCHEMBL13164008 | 0.62 | THRB (0.56) | ALDH1A1TP53MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110275584-A1 | PREVENTION AND TREATMENT OF INFLAMMATION-INDUCED AND/OR IMMUNE-MEDIATED BONE LOSS | ONEPHARM RESEARCH AND DEVELOPMENT GMBH (AT) | 2011-11-10 | — | — | US | disclosed |
| US-20110275584-A1 | PREVENTION AND TREATMENT OF INFLAMMATION-INDUCED AND/OR IMMUNE-MEDIATED BONE LOSS | ONEPHARM RESEARCH AND DEVELOPMENT GMBH (AT) | 2011-11-10 | — | — | US | disclosed |
| US-20100087413-A1 | Prevention and treatment of inflammation-induced and/or immune-mediated bone loss | ONEPHARM RESEARCH AND DEVELOPMENT GMBH (AT) | 2010-04-08 | — | — | US | disclosed |
| US-20080153791-A1 | 11Beta -Hydroxysteroid Dehydrogenases | ONPHARM GMBH (CH) | 2008-06-26 | — | — | US | disclosed |
| US-20080153791-A1 | 11Beta -Hydroxysteroid Dehydrogenases | ONPHARM GMBH (CH) | 2008-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153791-A1 | 11Beta -Hydroxysteroid Dehydrogenases | HSD11B1, HSD11B2, HSD17B1 | SMN1; SMN2 4224/4885HTT 2490/4885KMT2A 4363/4885 |
| US-20110275584-A1 | PREVENTION AND TREATMENT OF INFLAMMATION-INDUCED AND/OR IMMUNE-MEDIATED BONE LOSS | MMP1, MMP11, HSD11B2 | SMN1; SMN2 3706/4885HTT 3339/4885KMT2A 2945/4885 |
| US-20100087413-A1 | Prevention and treatment of inflammation-induced and/or immune-mediated bone loss | MMP1, HSD11B1, HSD11B2 | SMN1; SMN2 3735/4885HTT 3290/4885KMT2A 2876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.