Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ANXA2 | P07355 | 1/20 | 0.46 |
| ▸ | S100A10 | P60903 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.45 |
| ▸ | FPR1 | P21462 | 5/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18177329 | 0.91 | CYP2C9 (0.52) | ALDH1A1KDM4EHPGDTDP1CYP2C9 | |
| SCHEMBL2234193 | 0.82 | ANXA2 (0.67) | ALDH1A1KDM4EHPGDTDP1CYP2C9 | |
| SCHEMBL2233839 | 0.77 | ANXA2 (0.68) | ALDH1A1KDM4EHPGDTDP1CYP2C9 | |
| SCHEMBL12668751 | 0.75 | ALDH1A1 (0.69) | ALDH1A1KDM4ESMN1; SMN2MAPTRXFP1 | |
| SCHEMBL13927439 | 0.74 | ALDH1A1 (0.52) | ALDH1A1KDM4EHPGDTDP1CYP2C9 | |
| SCHEMBL11805654 | 0.72 | CYP1A2 (0.61) | ALDH1A1HPGDCYP2C9SMN1; SMN2GAA | |
| SCHEMBL12259135 | 0.72 | SMN1; SMN2 (0.60) | ALDH1A1HPGDCYP2C9SMN1; SMN2TP53 | |
| SCHEMBL1897477 | 0.71 | ALDH1A1 (0.71) | ALDH1A1KDM4ETDP1MAPTRXFP1 | |
| SCHEMBL18219843 | 0.71 | TSHR (0.52) | ALDH1A1KDM4EHPGDSMN1; SMN2GAA | |
| SCHEMBL16500230 | 0.71 | KDM4E (0.71) | ALDH1A1KDM4EHPGDSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110275584-A1 | PREVENTION AND TREATMENT OF INFLAMMATION-INDUCED AND/OR IMMUNE-MEDIATED BONE LOSS | ONEPHARM RESEARCH AND DEVELOPMENT GMBH (AT) | 2011-11-10 | — | — | US | disclosed |
| US-20110275584-A1 | PREVENTION AND TREATMENT OF INFLAMMATION-INDUCED AND/OR IMMUNE-MEDIATED BONE LOSS | ONEPHARM RESEARCH AND DEVELOPMENT GMBH (AT) | 2011-11-10 | — | — | US | disclosed |
| US-20100087413-A1 | Prevention and treatment of inflammation-induced and/or immune-mediated bone loss | ONEPHARM RESEARCH AND DEVELOPMENT GMBH (AT) | 2010-04-08 | — | — | US | disclosed |
| US-20100087413-A1 | Prevention and treatment of inflammation-induced and/or immune-mediated bone loss | ONEPHARM RESEARCH AND DEVELOPMENT GMBH (AT) | 2010-04-08 | — | — | US | disclosed |
| US-20080153791-A1 | 11Beta -Hydroxysteroid Dehydrogenases | ONPHARM GMBH (CH) | 2008-06-26 | — | — | US | disclosed |
| US-20080153791-A1 | 11Beta -Hydroxysteroid Dehydrogenases | ONPHARM GMBH (CH) | 2008-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153791-A1 | 11Beta -Hydroxysteroid Dehydrogenases | HSD11B1, HSD11B2, HSD17B1 | ALDH1A1 174/4885KDM4E 3388/4885HPGD 29/4885 |
| US-20110275584-A1 | PREVENTION AND TREATMENT OF INFLAMMATION-INDUCED AND/OR IMMUNE-MEDIATED BONE LOSS | MMP1, MMP11, HSD11B2 | ALDH1A1 248/4885KDM4E 2532/4885HPGD 48/4885 |
| US-20100087413-A1 | Prevention and treatment of inflammation-induced and/or immune-mediated bone loss | MMP1, HSD11B1, HSD11B2 | ALDH1A1 241/4885KDM4E 2388/4885HPGD 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.