SCHEMBL18180597

SCHEMBL18180597

Cc1ccc(CC(=O)Nc2sc(C)c(C)c2C(N)=O)cc1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.66
AIP O00170 1/20 0.62
SGTA O43765 1/20 0.62
TOMM70 O94826 1/20 0.62
STIP1 P31948 1/20 0.62
PPP5C P53041 1/20 0.62
FKBP4 Q02790 1/20 0.62
PPID Q08752 1/20 0.62
FKBP5 Q13451 1/20 0.62
FKBP8 Q14318 1/20 0.62
TOMM34 Q15785 1/20 0.62
DNAJC7 Q99615 1/20 0.62
AIPL1 Q9NZN9 1/20 0.62
STUB1 Q9UNE7 1/20 0.62
MAPK8 P45983 2/20 0.60
MAPT P10636 5/20 0.60
ALDH1A1 P00352 7/20 0.58
HPGD P15428 2/20 0.58
HSD17B10 Q99714 2/20 0.58
APOBEC3G Q9HC16 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18177310 0.85 MAPT (0.61) L3MBTL1AIPSGTATOMM70STIP1
SCHEMBL13126361 0.83 MAPK8 (0.65) L3MBTL1AIPSGTATOMM70STIP1
SCHEMBL7676531 0.80 MAPK8 (0.63) L3MBTL1AIPSGTATOMM70STIP1
SCHEMBL31060214 0.75 MAPK8 (1.00) L3MBTL1AIPSGTATOMM70STIP1
SCHEMBL13126363 0.75 MAPK8 (1.00) L3MBTL1AIPSGTATOMM70STIP1
SCHEMBL7005070 0.73 MAPK8 (0.63) MAPK8MAPTALDH1A1HPGDSMN1; SMN2
SCHEMBL11324603 0.73 AIP (0.66) L3MBTL1AIPSGTATOMM70STIP1
SCHEMBL6999034 0.73 MAPK8 (0.68) AIPSGTATOMM70STIP1PPP5C
SCHEMBL7670751 0.72 MAPK8 (0.67) AIPSGTATOMM70STIP1PPP5C
SCHEMBL7886663 0.72 MAPK8 (0.55) L3MBTL1AIPSGTATOMM70STIP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160310528-A1 Castration-Resistant Prostate Cancer NUTECH VENTURES 2016-10-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160310528-A1 Castration-Resistant Prostate Cancer UGDH, G6PD, DPYD L3MBTL1 2698/4885AIP 1856/4885SGTA 3005/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.